Metabolism and Mental Illness

Trends in Molecular Medicine
Matija Sestan-Pesa, Tamas L Horvath

Abstract

Over the past century, overwhelming evidence has emerged pointing to the hypothalamus of the central nervous system (CNS) as a crucial regulator of systemic control of metabolism, including appetite and feeding behavior. Appetite (or hunger) is a fundamental driver of survival, involving complex behaviors governed by various parts of the brain, including the cerebral cortex. Here, we provide an overview of basic metabolic principles affecting the CNS and discuss their relevance to physiological and pathological conditions of higher brain functions. These novel perspectives may well provide new insights into future research strategies to facilitate the development of novel therapies for treating mental illness.

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Citations

Aug 9, 2016·Trends in Molecular Medicine·Chanan MeydanHermona Soreq
Mar 25, 2017·The International Journal of Neuropsychopharmacology·Maria Lindskog
May 17, 2018·Cell and Tissue Research·Hans-Gert BernsteinJohann Steiner
May 21, 2020·Journal of Cellular Physiology·Alessandro IeraciMassimiliano Ruscica
Oct 28, 2018·Cell Death & Disease·Tongtong GeBingjin Li
Oct 28, 2020·Nature Metabolism·Maria Consolata MilettaTamas L Horvath
Oct 17, 2017·Biological Psychiatry·Annadora J Bruce-KellerHans-Rudolf Berthoud

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