PMID: 3759228Oct 1, 1986Paper

Metabolism and storage of catecholamines in rats with pheochromocytoma implants

Hypertension
N T BuuR N Chute

Abstract

New England Deaconess Hospital rats implanted with a pheochromocytoma P259 became hypertensive and showed high concentrations of plasma dopamine (42.0 +/- 14.6 ng/ml) and norepinephrine (45.7 +/- 8.4 ng/ml). However, the norepinephrine content of several peripheral tissues of these rats did not differ from those of the New England Deaconess Hospital control rats, and their dopamine content, although slightly higher, was much lower than would have been expected from the plasma dopamine levels. Methylation by catechol-O-methyltransferase did not appear to play a major role in the inactivation of tissue catecholamines since there were no noticeable increases of normetanephrine or 3-methoxytyramine in the tissues of the rats with pheochromocytoma. There was also no increase in conjugated dopamine, in either the sulfate or glucuronide form, in the plasma or tissue of the hypertensive rats, although injection of L-dopa induced a large increase in dopamine sulfate in the plasma and urine of these rats. This finding indicated that, although their sulfoconjugation mechanism was intact and not affected by the pheochromocytoma, it did not participate in the metabolism of dopamine released by the tumor into the blood. On the other hand, pl...Continue Reading

References

Sep 27, 1979·The New England Journal of Medicine·E L BravoB H Stewart
Feb 1, 1972·Cancer·S Warren, R N Chute
Apr 1, 1984·Endocrinology·G TsujimotoB B Hoffman
Sep 1, 1982·Hypertension·O KuchelO Serri
May 1, 1962·Acta Physiologica Scandinavica·A CARLSSON, N A HILLARP

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Citations

Nov 21, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·R J SlingerlandA H Van Gennip
Nov 20, 2019·Molecular Genetics & Genomic Medicine·José Luis RoyoArmando Reyes-Engel

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