PMID: 8462776Mar 1, 1993Paper

Metabolism by human endothelial cells of very low density lipoprotein subfractions isolated from type 1 (insulin-dependent) diabetic patients

Diabetologia
R L Klein, M F Lopes-Virella

Abstract

The very low density lipoprotein (VLDL) fraction was isolated from 11 normolipidaemic Type 1 (insulin-dependent) diabetic patients in good to fair glycaemic control and from 11 age-, sex- and race-matched, non-diabetic, control subjects. The rate of receptor-mediated degradation by human endothelial cells was significantly greater (p < 0.02) for the total VLDL fraction isolated from diabetic patients compared to control subjects and averaged 1008 +/- 300 and 717 +/- 150 ng.mg cell protein-1.16 h-1, respectively. The total VLDL fraction was separated into three subfractions: VLDL-I, Sf 100-400 (Sf = Svedberg units); VLDL-II, Sf 60-100; VLDL-III, Sf 20-60. Rates of receptor-mediated degradation of VLDL-I and VLDL-II isolated from diabetic patients were significantly greater than the comparable subfraction isolated from control subjects and averaged 1023 +/- 279 vs 361 +/- 122 (p < 0.01) and 433 +/- 70 vs 294 +/- 70 ng.mg cell protein-1.16 h-1 (p < 0.03), respectively. Rates of receptor-mediated degradation of the V-III subfraction isolated from the two groups did not differ significantly. There were no significant differences in the chemical composition or in the plasma concentrations of the VLDL subfractions isolated from diabet...Continue Reading

References

Feb 26, 1991·Biochimica Et Biophysica Acta·H MokunoF Takaku
Jul 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·S C BlackJ P Reckless
Nov 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A Stiko-RahmJ Nilsson
Jan 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·T L InnerarityR W Mahley
Feb 1, 1985·The Journal of Clinical Investigation·E S KrulG Schonfeld
Jun 1, 1985·The Tohoku Journal of Experimental Medicine·R SanoT Toyota
Nov 1, 1973·The Journal of Clinical Investigation·E A JaffeR L Nachman
Nov 1, 1983·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·V W van HinsberghM Scheffer
May 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D P BakerJ A Berliner
Mar 1, 1980·The Journal of Clinical Endocrinology and Metabolism·J M FalkoR Steelman

❮ Previous
Next ❯

Citations

Oct 1, 1994·Diabetes/metabolism Reviews·G H Tomkin, D Owens
Oct 10, 1997·Metabolism: Clinical and Experimental·T R ThomasW S Harris
Jan 24, 1998·Metabolism: Clinical and Experimental·A L Kennedy, T J Lyons

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.