PMID: 6829959Mar 1, 1983

Metabolism by rat hepatic microsomes of fluorinated ether anesthetics following ethanol consumption

Anesthesiology
S A RiceR I Mazze

Abstract

The possibility that the metabolism of volatile inhalational anesthetics is altered following chronic ethanol consumption was investigated in male Fischer 344 rats. The hepatic microsomal defluorination rates of methoxyflurane, enflurane, and sevoflurane were determined for pair-fed rats receiving ethanol with normal caloric or with 50% of normal caloric intake. For comparison, the effects of phenobarbital treatment on anesthetic defluorination rates also were examined. Fourteen days of ad libitum consumption of 16% ethanol resulted in maximal defluorination rates of the above anesthetics. No overt signs of ethanol toxicity were observed. Ethanol-treated rats with a normal caloric intake had significantly increased microsomal defluorination rates per mg protein compared with pair-fed control rats as follows: methoxyflurane, 190% of control; enflurane, 298% of control; and sevoflurane, 301% of control. Ethanol-treated animals with 50% of normal caloric intake showed similar elevations in microsomal defluorination rates when compared with pair-fed controls. Phenobarbital treatment significantly increased the rate of methoxyflurane defluorination (673% of control), whereas the rates of sevoflurane defluorination (127% of control) ...Continue Reading

Citations

Sep 1, 1984·Brain Research Bulletin·P S Lasiter, J Garcia
Apr 1, 1990·Alcoholism, Clinical and Experimental Research·R TsutsumiC S Lieber
Jan 1, 1997·European Journal of Anaesthesiology·N E Mikatti, T E Healy
Nov 1, 1983·Anaesthesia and Intensive Care·M J CousinsJ L Plummer
Dec 1, 1995·Anesthesia and Analgesia·E D Kharasch

Related Concepts

Ultane
Ethanol
Anesthetic Effect
Energy Intake
Cytochrome P-450 Oxygenase
Enlirane
Ethers
Anecotan
Methyl Ethers
Microsomes, Liver

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