PMID: 7090421Feb 1, 1982Paper

Metabolism in the rat of potassium DL-octan-2-sulphate, a secondary alkyl sulphate

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
J L MaggsA H Olavesen

Abstract

1. The metabolism of potassium [2-14C]octan-2-sulphate and potassium octan-2-[35S]sulphate was investigated in the rat. Following oral administration, the bulk of the radioactivity was eliminated in the urine within 24 h. 2. Whole-body radioautography showed the liver to be the principal site of tissue accumulation of radiolabel following administration of 14C- or 35S-labelled DL-octan-2-sulphate. 3. Octan-2-sulphate was extensively degraded in vivo. The major urinary components are five sulphate estes, present in urine in essentially the same proportions regardless of label. The relative proportions of radioactivity associated with the urinary components showed considerable differences between male and female rats. 4. Three of the components have been identified as butanoate-3-sulphate, hexanoate-5-sulphate and octanoate-7-sulphate. The remaining metabolite was tentatively identified as an aldehyde derivative of octan-2-sulphate, a possible intermediate in the formation of octanoate-7-sulphate.

References

Jul 1, 1978·Toxicology and Applied Pharmacology·A J TaylorD Howes
Mar 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B BurkeG M Powell
Nov 1, 1976·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B BurkeG M Powell
Aug 1, 1975·The Biochemical Journal·J W Fitzgerald
Sep 1, 1975·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B BurkeG M Powell
Jan 1, 1973·Antonie van Leeuwenhoek·G W Lijmbach, E Brinkhuis
May 1, 1968·Toxicology and Applied Pharmacology·W R Michael
Jan 1, 1969·The Biochemical Journal·W H DennerK S Dodgson
Oct 1, 1967·Biochemical Pharmacology·G M PowellK S Dodgson
Jan 1, 1981·Journal of Inherited Metabolic Disease·N G Kennaway, H C Curtis

Citations

Mar 1, 1984·Biochemical Pharmacology·J L MaggsC G Curtis
Jun 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S K BainsG M Powell
Oct 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J L MaggsA H Olavesen
Dec 1, 1985·Scandinavian Journal of Gastroenterology·F KuipersR J Vonk

Related Concepts

Potassium octan-2-sulfate
Autoradiography
Carbon Radioisotopes
Chromatography, Gas-Liquid
Liver
Chromatography, Gas-Liquid-Mass Spectrometry
Isooctanes
August Rats
Sulfur Radioisotopes

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