Metabolism of 2-phenylethylamine and phenylacetaldehyde by precision-cut guinea pig fresh liver slices

European Journal of Drug Metabolism and Pharmacokinetics
Georgios I PanoutsopoulosChristine Beedham

Abstract

2-Phenylethylamine is an endogenous constituent of human brain and is implicated in cerebral transmission. It is also found in certain foodstuffs and may cause toxic side-effects in susceptible individuals. Metabolism of 2-phenylethylamine to phenylacetaldehyde is catalyzed by monoamine oxidase and the oxidation of the reactive aldehyde to its acid derivative is catalyzed mainly by aldehyde dehydrogenase and perhaps aldehyde oxidase, with xanthine oxidase having minimal transformation. The present investigation examines the metabolism of 2-phenylethylamine to phenylacetaldehyde in liver slices and compares the relative contribution of aldehyde oxidase, xanthine oxidase and aldehyde dehydrogenase activity in the oxidation of phenylacetaldehyde with precision-cut fresh liver slices in the presence/absence of specific inhibitors of each enzyme. In liver slices, phenylacetaldehyde was rapidly converted to phenylacetic acid. Phenylacetic acid was the main metabolite of 2-phenylethylamine, via the intermediate phenylacetaldehyde. Phenylacetic acid formation was completely inhibited by disulfiram (specific inhibitor of aldehyde dehydrogenase), whereas isovanillin (specific inhibitor of aldehyde oxidase) inhibited acid formation to a l...Continue Reading

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Citations

Jan 8, 2013·Applied Biochemistry and Biotechnology·Mohammad-Reza RashidiAkram Faridi
Mar 21, 2007·Chemistry & Biodiversity·Bernard Testa, Stefanie D Krämer
Aug 30, 2016·Frontiers in Microbiology·Fausto GardiniFatih Özogul
Jan 25, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Georgios I Panoutsopoulos, Christine Beedham
Jun 16, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Georgios Panoutsopoulos
Mar 18, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Georgios I Panoutsopoulos
Jun 24, 2014·Archiv der Pharmazie·Maryam Hamzeh-MivehroudMohammad-Reza Rashidi
Aug 19, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Evan C RosenbergOrrin Devinsky
Oct 21, 2016·Clinical Pharmacokinetics·Gail D Anderson, Lingtak-Neander Chan
Sep 22, 2010·Journal of Medicinal Chemistry·David C PrydeThien-Duc Tran
Oct 19, 2004·Chemical Research in Toxicology·Georgios I PanoutsopoulosChristine Beedham

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