PMID: 3758941Sep 1, 1986Paper

Metabolism of 24-norlithocholic acid in the rat: formation of hydroxyl- and carboxyl-linked glucuronides and effect on bile flow

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
K E ShattuckJ St Pyrek

Abstract

24-Norlithocholic (3 alpha-hydroxy-24-nor-5 beta-cholan-23-oic) acid is the lower homologue of lithocholic acid, a potent cholestatic agent. In order to characterize its cholestatic potential and metabolic fate, 3 beta-tritiated 24-norlithocholate was infused intravenously into adult male Sprague-Dawley rats prepared with an external biliary fistula. The results demonstrate that 24-norlithocholate does not induce cholestasis in rats when administered in doses in excess of those necessary for lithocholate to produce cholestasis. Hydroxyl- and carboxyl-linked glucuronides were identified as major metabolites secreted in the bile. Especially noteworthy is the identification of carboxyl-linked glucuronides of mono-, di- and trihydroxylated C23 bile acids. Their total amount (25% of recovered radioactive products) is comparable to that of the hydroxyl-linked glucuronide of 24-norlithocholic acid (41%). In this study, for the first time, a bile acid diglucuronide, substituted both at 3-hydroxyl and carboxyl groups, was detected (11%).

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Citations

Jun 22, 1992·Biochimica Et Biophysica Acta·I PanfilA Radominska
Mar 16, 1994·Biochimica Et Biophysica Acta·A RadominskaP I Mackenzie
May 20, 1998·Steroids·J GotoS Ikegawa
Jan 15, 1988·European Journal of Biochemistry·M ParquetA Raizman
Jul 1, 1987·The Journal of Clinical Investigation·A Radomińska-PyrekJ St Pyrek
Feb 15, 2016·Clinics and Research in Hepatology and Gastroenterology·Heiko S SchadtGerd A Kullak-Ublick
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alan F Hofmann
Jun 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R P Oude ElferinkP L Jansen
Mar 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R B KirkpatrickT R Tephly
Apr 21, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Upendra A Argikar

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