Metabolism of 3-(hydroxymethyl)-8-methoxychromone in the rat. II. Classification and identification of urinary drug metabolites

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
M C CrewJ Di Carlo


1. Five metabolites were isolated from the urine of dogs dosed with 3-(hydroxymethyl)-8-methoxy[4-14C]chromone. These were identified as 8-methoxychromone, 2-hydroxy-3-methoxyacetophenone, 3-(hydroxymethyl)-8-hydroxychromone, 8-hydroxychromone and 2,3-dihydroxyacetophenone. 2. These compounds were also present in the urine of rats treated with labelled drug, together with unchanged drug and two intermediate metabolites, 3-carboxy-8-methoxychromone and 3-(carboxymethyl)-8-hydroxychromone. 3. In addition to the unconjugated labelled compounds, glucuronides and sulphates were identified. 4. Quantitative data were obtained for all of the 20 labelled compounds in rat urine. 5. A scheme is presented for the biotransformation of 3-(hydroxymethyl)-8-methoxychromone in rats and dogs, and a mechanism for scission of the gamma-pyrone ring is suggested.


Feb 1, 1976·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M C CrewF J Di Carlo
Nov 1, 1970·Toxicology and Applied Pharmacology·M J AshtonJ T Ritchie
Jul 1, 1972·The Journal of Pharmacy and Pharmacology·S R WalkerJ W Paterson
Nov 1, 1959·Archives of Biochemistry and Biophysics·M S MASRIF DE EDS


Jan 1, 1985·Drug Metabolism Reviews·D A SmithM G Neale
Aug 9, 2011·Regulatory Toxicology and Pharmacology : RTP·Barry LynchAshley Roberts
Feb 1, 1976·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M C CrewF J Di Carlo

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