PMID: 589448Nov 4, 1977

Metabolism of [3H]serotonin in the marine mollusc, Aplysia californica

Brain Research
J E Goldman, J H Schwartz


The fate of serotonin was studied in several tissues of the marine mollusc, Aplysia californica. When isolated nervous tissue was bathed in [3H]serotonin, two radioactive derivatives were formed; both appeared to be sugar conjugates: the first, possibly of glucuronic acid, and the second, of a more complex sugar moiety. When [3H]serotonin was injected directly into cell bodies of identified neurons, both serotonergic and non-serotonergic, only the conjugate which behaved as the glucuronide was formed. [3H]Serotonin was also converted only to this substance during incubation with isolated heart, kidney and hemolymph. Metabolic activity of the blood resided within cellular elements. No evidence of oxidative deamination was found in any tissue. In contrast to serotonin, however, [3H]tryptamine was readily oxidized to indoleacetic acid by nervous tissue.


Aug 1, 1976·The Journal of Cell Biology·J E GoldmanJ H Schwartz
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M EisenstadtJ H Schwartz
Jun 1, 1965·Biochemical Pharmacology·M M AiraksinenJ Huttunen
Feb 15, 1959·Experientia·M GOLDSTEINC SIMMONS
Apr 1, 1961·Biochemical Pharmacology·K HARTIALA
Jan 1, 1963·Comparative Biochemistry and Physiology·G A KERKUT, G A Cottrell
Aug 1, 1962·Proceedings of the National Academy of Sciences of the United States of America·D NATHANSN D ZINDER
Apr 1, 1962·Analytical Biochemistry·M A NAUGHTON, H HAGOPIAN


Jan 1, 1983·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·C Stein, D Weinreich
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J H SchwartzD J Goldberg
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D J GoldbergJ H Schwartz
Nov 7, 2012·Plant & Cell Physiology·Thomas L SlewinskiRobert Turgeon

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