Metabolism of 4-hydroxy-2,3-pentene-1-al in submitochondrial fractions of mouse liver

Chemico-biological Interactions
S F Hakki, J T Nodes


The location of the enzymic system involved in the metabolism of 4-hydroxy-2-3-pentene-1-al (HPE) in the livers of female mice (CBA/CA) has been established. All mitochondrial membranes showed some activity with slightly higher metabolism in the matrix. The enzymic system had a pH optimum of 8.8 using pyrophosphate buffer. Suitable marker enzymes were used to test the contamination of the different submitochondrial fractions with each other.


Apr 1, 1975·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P J ConroyG W White
Apr 1, 1975·Archives of Biochemistry and Biophysics·A A Horton, M C Barrett
Jul 27, 1975·Biochimica Et Biophysica Acta·T Koivula, M Koivusalo


Mar 21, 1986·Biochimica Et Biophysica Acta·H EsterbauerM Comporti
Jan 1, 1985·The International Journal of Biochemistry·M F Kenel, A P Kulkarni
Jan 1, 1989·Free Radical Biology & Medicine·G Witz

Related Concepts

Hydrogen-Ion Concentration
Intracellular Membranes
Mitochondria, Liver
Mouse, Swiss

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.