PMID: 9174248May 20, 1997Paper

Metabolism of [5-(3)H]kynurenine in the developing rat brain in vivo: effect of intrastriatal ibotenate injections

Brain Research. Developmental Brain Research
G CeresoliR Schwarcz

Abstract

Two metabolites of the kynurenine pathway of tryptophan degradation, the neurotoxin quinolinic acid (QUIN) and the neuroprotectant kynurenic acid (KYNA), may play a role in the initiation or propagation of brain diseases. In order to study their disposition during the acute and chronic stages of neurodegeneration, effects of an excitotoxic insult on the de novo synthesis of several kynurenine pathway metabolites were examined in vivo. Neuronal injury and lesions were produced in 7-day (PND 7), 14-day (PND 14) and young adult rats by an intrastriatal injection of the excitotoxin ibotenic acid. At 2 h, 2, 7 and 28 days later, the formation of tritiated KYNA, 3-hydroxykynurenine (3HK), xanthurenic acid and QUIN was assessed after an acute intrastriatal injection of their common bioprecursor, [5-(3)H]kynurenine. In all three age groups, the acute insult resulted in a shift towards enhanced KYNA formation, as indicated by 2-4 fold decreases in the 3HK/KYNA and QUIN/KYNA ratios in ibotenate-treated striata. At later post-lesion intervals, age-specific several-fold changes were observed in the flux through both the KYNA and QUIN branches of the kynurenine pathway. With aging, kynurenine conversion to QUIN and especially to 3HK, became...Continue Reading

References

Aug 1, 1975·Hoppe-Seyler's Zeitschrift für physiologische Chemie·T NoguchiR Kido
Jan 1, 1990·Journal of Neurochemistry·C Speciale, R Schwarcz
Jun 19, 1989·Brain Research·R SchwarczR J White
Aug 21, 1987·European Journal of Pharmacology·J W McDonaldM V Johnston
Nov 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W D DietrichR Busto
Mar 3, 1994·The New England Journal of Medicine·S A Lipton, P A Rosenberg
Apr 2, 1993·Science·H Komuro, P Rakic
Nov 1, 1995·Human & Experimental Toxicology·P Goldfarb
Jul 15, 1996·European Journal of Biochemistry·D Alberati-GianiA M Cesura
Mar 29, 1996·Brain Research. Developmental Brain Research·G CeresoliR Schwarcz
Jan 1, 1992·The European Journal of Neuroscience·Hui-Qiu WuRobert Schwarcz

❮ Previous
Next ❯

Citations

Jun 22, 2006·Neurotoxicity Research·K H JhamandasK A Lipic
Mar 20, 2014·Neurodegenerative Disease Management·Zsófia Majláth, László Vécsei
Feb 24, 2012·Pharmacological Reports : PR·Robert RejdakEberhart Zrenner
Jan 10, 2008·Journal of Neurochemistry·Serge GobailleMichel Maitre
Feb 20, 2009·Journal of Neurochemistry·Laura AmoriRobert Schwarcz
Aug 12, 2016·Neuropharmacology·Robert Schwarcz, Trevor W Stone
Jul 31, 2001·Pediatric Research·G Ceresoli-Borroni, R Schwarcz
Sep 27, 2013·Nutrients·Fahad Alshahrani, Naji Aljohani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.