PMID: 6108199Jan 1, 1980Paper

Metabolism of a glutathione conjugate in human fetal and adult tissues

Developmental Pharmacology and Therapeutics
P MoldéusA Rane

Abstract

Human fetal and adult liver was found to catalyze the metabolism of a glutathione conjugate, acetaminophen-glutathione, to the cysteine conjugate. The activity was higher in the fetal than in the adult liver, 4.06 +/- 0.59 and 1.63 +/- 0.42 nmol/10 min/mg protein, respectively. The initial reaction was catalyzed by gamma-glutamyltransferase, as indicated by the inhibitory effect of serine-borate. The hydrolysis of the formed cysteinylglycine conjugate was extremely rapid since no conjugate was detected and an almost stoichiometric formation of acetaminophen-cysteine from acetaminophen-glutathione was observed. The human fetal kidney also metabolized acetaminophen-glutathione to the corresponding conjugate. This activity was, however, lower than in the liver from the same fetus.

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