PMID: 43220Nov 1, 1979

Metabolism of acebutolol-d6 in the rat correlates with the identification of a new metabolite in human urine

Drug Metabolism and Disposition : the Biological Fate of Chemicals
B D Andresen, F T Davis


The metabolism and excretion of acebutolol-d6, [1-(2-acetyl-4-n-butyramido-phenoxy)-2-hydroxy-3--[2H6]isopropylaminopropane] has been studied in the rat. Metabolites were characterized by thin-layer and gas chromatography, mass spectrometry, and the direct comparisons of metabolites to synthetic standards. Approximately 60% of the parent drug was excreted unchanged. Two major metabolites, an acetamide and an aniline, were identified in urine samples at relative concentrations of approximately 10% and 30%, respectively. The aniline analog of acebutolol was also identified in human urine.

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