PMID: 6409150Aug 1, 1983Paper

Metabolism of arachidonic acid and prostanoids in human endometrial stromal cells in monolayer culture

Biochimica Et Biophysica Acta
K KorteM L Casey

Abstract

In the present investigation, we compared the metabolism of arachidonic acid in human endometrial stromal cells maintained in monolayer culture with that in human decidual tissues. By gas-chromatographic analysis, the distribution of arachidonic acid in glycerophospholipids and in the neutral lipids of decidual tissues and stromal cells in culture was similar. After the addition of [14C]arachidonic acid to the culture medium, steady-state conditions with respect to radioactive labeling of the lipids of the cells were attained after 24 h, except for phosphatidylethanolamine and neutral lipids. The percentage distribution of [14C]arachidonic acid in the lipids of the cells in culture was as follows: phosphatidylcholine, 41%; phosphatidylserine, 5%; phosphatidylinositol, 19%; phosphatidylethanolamine, 22%; neutral lipids, 11%. This distribution of arachidonic acid among the lipids is similar to that in decidual tissue, except for that in phosphatidylethanolamine. The amount of radioactivity in phosphatidylethanolamine continued to increase up to 72 h whereas that in neutral lipids declined after a maximum amount was present at 4 h. In the cells in monolayer culture, [14C]prostaglandin E2 and [14C]prostaglandin F2 alpha were produc...Continue Reading

References

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Citations

Sep 1, 1986·Prostaglandins, Leukotrienes, and Medicine·O IshiharaK Satoh
Apr 30, 2010·The Journal of Clinical Endocrinology and Metabolism·Anna SokalskaAntoni J Duleba
Dec 1, 1986·American Journal of Obstetrics and Gynecology·S NiesertM L Casey
Aug 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S K Smith, R W Kelly
Apr 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S B RodanG A Rodan
Sep 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R RomeroM D Mitchell
Jan 1, 1991·Annals of the New York Academy of Sciences·D SemerM L Casey
Mar 7, 1986·Journal of Chromatography·K KorteM L Casey

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