PMID: 6987286Apr 1, 1980Paper

Metabolism of arachidonic acid in inflamed human gingivae. I.: Formation of 6-keto-prostaglandin F1 alpha

Journal of Dental Research
P Y WongF D Sticht

Abstract

Incubation of [14C]-arachidonic acid with slices of inflamed human gingivae in the absence of glutathione resulted in formation of 6-keto-PGF1 alpha, the stable hydrolytic product of prostacyclin. Significantly smaller amounts of this product were obtained when normal gingivae were treated in a similar manner. The formation of prostacyclin in inflamed gingivae may play an important role in alveolar bone resorption and as a mediator of inflammation in periodontal disease.

Citations

Oct 1, 1987·Prostaglandins, Leukotrienes, and Medicine·T M elAttarR D Platt
Jan 1, 1985·Journal of Periodontology·C F MendietaJ C Romero
Mar 1, 1986·Journal of Periodontal Research·T M elAttarJ M Goodson
Mar 1, 1983·Journal of Periodontal Research·F E DewhirstJ M Goodson
Aug 18, 2012·International Journal of Dentistry·M T PöllänenV-J Uitto
Oct 1, 1982·The Anatomical Record·P SiriguM T Perra
Jun 1, 1982·Journal of Dental Research·B SidhagenB B Fredholm
Jan 1, 1997·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·R NiedermanS Kashket
Apr 1, 1989·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·U H LernerO Ljunggren
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·T H Howell, R C Williams

Related Concepts

Eicosatetraenoic Acids
Carbon Radioisotopes
Chromatography
Thin Layer Chromatography
Interdental Papilla
Gingivitis
Prostaglandins
Prostaglandins F
Flolan

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