PMID: 6170507Jan 1, 1981Paper

Metabolism of asialotranscortin by hepatocytes and cortisol binding to hepatocytes

Endocrine Research Communications
K L Hossner, R B Billiar

Abstract

Binding and catabolism of iodinated human transcortin and asialotranscortin were studied in isolated rat hepatocytes. Human transcortin binding to hepatocytes was very low (less than 3%) while 40-60% of the asialotranscortin bound to the hepatocytes. Asialofetuin inhibited asialotranscortin binding to hepatocytes, producing 50% inhibition of binding at 5 x 10-9M, but had no effect on transcortin binding. The lysosomal inhibitors leupeptin (0.05 mM) and ammonium chloride (10 mM) had no effect on asialotranscortin binding but prevented the latter's catabolism, suggesting lysosomal involvement in asialotranscortin degradation. Both transcortin and asialotranscortin inhibited the binding of [3H]cortisol to the hepatocytes in a dose-dependent manner.

References

Apr 1, 1977·European Journal of Biochemistry·H KirschkeP Bohley
Nov 1, 1975·The Biochemical Journal·J H LaBadieN N Aronson
Aug 25, 1977·Biochimica Et Biophysica Acta·H TolleshaugK R Norum
Apr 1, 1979·Acta Endocrinologica·Y Suzuki, H Sinohara
Jun 1, 1979·Biochimica Et Biophysica Acta·H TolleshaugK R Norum
Jul 18, 1979·Biochimica Et Biophysica Acta·K L Hossner, R B Billiar
Oct 18, 1979·Biochimica Et Biophysica Acta·G R Hildenbrandt, N N Aronson
Jul 1, 1974·Archives of Biochemistry and Biophysics·H Van Baelen, G Mannaerts
Mar 1, 1972·Metabolism: Clinical and Experimental·R M Burton, U Westphal

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