PMID: 44035Oct 1, 1979

Metabolism of benzo[a]pyrene in isolated human scalp hair follicles

Toxicology
A J VermorkenH Bloemendal

Abstract

Human scalp hair follicles contain an enzyme system that metabolizes the carcinogen benzo[a]pyrene. The major ethyl acetate soluble metabolites are 7,8-dihydro-7,8-dihydroxybenzo[a]pyrene,9,10-dihydro-9,10-dihydroxybenzo[a]pyrene and 3-hydroxybenzo[a]pyrene. Addition of 1,1,1-trichloropropene-2,3-oxide (TCPO), an inhibitor of epoxide hydratase, prevents the formation of the dihydrodiols. The overall metabolism can be inhibited by the addition of alpha-naphthoflavone. The metabolism of benzo[a]pyrene in a cell culture of human scalp hair follicles has also been investigated. The results show that the activity of arylhydrocarbon hydroxylase (AHH) and epoxide hydratase (EH) is maintained in culture.

References

Apr 1, 1985·Archives of Toxicology·M W HukkelhovenA J Vermorken
Oct 31, 1980·Molecular Biology Reports·P J WeteringsH Bloemendal
Nov 30, 1981·Molecular Biology Reports·M W HukkelhovenH Bloemendal
Jan 1, 1996·International Journal of Legal Medicine·L Pötsch
Apr 1, 1986·Cancer Letters·A C DijkstraA J Vermorken
Sep 15, 1982·Analytical Biochemistry·M W HukkelhovenH Bloemendal
Jan 1, 1990·Drug Metabolism Reviews·J Kao, M P Carver
Sep 1, 1981·Experimental Eye Research·C M GoosH Bloemendal
Jan 1, 1982·Clinical Genetics·M W HukkelhovenH Bloemendal

Citations

Jun 1, 1979·The British Journal of Dermatology·A J VermorkenH Bloemendal
Jul 1, 1979·The British Journal of Dermatology·C H de BruynS J Geerts
Jun 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·P L GroverC Heidelberger
Nov 1, 1973·The New England Journal of Medicine·G KellermannM Luyten-Kellerman

Related Concepts

Downy Hair
Scalp Structure
Benzpyrene
Autoradiography
Metabolic Biotransformation
Hydrogen-Ion Concentration

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