Metabolism of beta-hexachlorocyclohexane-14C in rats following low dosing in the daily diet

Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
J P LayE Richter

Abstract

beta-Hexachlorocyclohexane-14C (1.5 ppm) was administered in the diet to rats for one week. During the elimination phase three therapeutic agents were fed to enhance the clearance. Renal and fecal excreted radioactive products were collected for 8 weeks and extracted. Although significant differences in the total excreted amount of radioactivity were registered between controls and treated rats, there were no quantitative differences in the extractability of the excreta and no differences in the chemical nature of metabolites found. Radioactivity in urine consisted to 100% of conversion products, about 30% of which were unextractable residues. In the organic soluble fraction the 2,4,6-trichlorophenol was the major metabolite in urine and the only metabolite detected in feces. Minor conversion products of beta-HCH in urine were a trichlorohydroxyme-thoxybenzene, a dichlorophenol and a trace of a tetrachlorocyclohexane-isomer.

References

Oct 27, 1975·Archives of Microbiology·C M Tu
Nov 1, 1975·Bulletin of Environmental Contamination and Toxicology·M SuzukiT Watanabe
Jan 1, 1977·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·A SzokolayJ Uhnak
Jun 10, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·K SteinW Koransky
Jan 1, 1979·Journal of Agricultural and Food Chemistry·E RichterF Korte
Aug 1, 1979·Toxicology and Applied Pharmacology·E RichterF Korte
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Jan 1, 1980·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K SteinG Noack

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Citations

Oct 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E B BritteboI Brandt
Sep 1, 1983·Archives of Environmental Contamination and Toxicology·S M Waliszewski, G A Szymczyński

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