PMID: 6967727Aug 1, 1980Paper

Metabolism of C4 and factor B in rheumatoid arthritis. Relation to rheumatoid factor

Arthritis and Rheumatism
R A KaplanJ H Vaughan

Abstract

Metabolic turnover determined by radioiodide labeled C4 and Factor B was studied in 18 patients with rheumatoid arthritis (RA) and 19 normal control subjects as a means of estimating the relative ratio of consumption of components in the classical and alternative pathways of complement activation. Predominance of fractional catabolic rate (FCR) of C4 over Factor B was demonstrated with differentially labeled C4 and Factor B. The hypercatabolism occurred in the extravascular space. C4 FCR correlated significantly with rheumatoid factor (RF) determined in a hemolytic assay (rs = 0.72), measured as IgG RF (rs = 0.57), and as IgM RF (rs = 0.45). There were no significant correlations with several other antibodies measured. These results are consistent with the hypothesis that RA is a systemic, extravascular immune complex disease, in which RF immune complexes play a significant pathogenetic role principally via activation of the classical pathway of complement.

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Citations

Jun 1, 1987·Diabetologia·J A CharlesworthN Howard
Jan 1, 1981·Springer Seminars in Immunopathology·D A CarsonJ H Vaughan
Apr 3, 1986·Journal of Immunological Methods·Y KanayamaJ G Curd
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Oct 1, 1987·Arthritis and Rheumatism·G Moxley, S Ruddy

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