Metabolism of cadaverine and pipecolic acid in brain and other organs of the mouse

Journal of Neuroscience Research
Y NomuraJ Ortiz

Abstract

Cadaverine and pipecolic acid metabolism was investigated in vitro in several organs of the mouse by measuring 14CO2 formation from labeled precursors. The liver showed the highest formation of 14CO2 from [1,5-14C]-cadaverine, whereas brain demonstrated a much lower formation. Anaerobiosis or inhibition of monoamineoxidase (MAO) activity significantly reduced 14CO2 formation in every organ, but inhibition of diamine oxidase (DAO) activity had no effect in brain and kidney. Piperidine was formed from cadaverine in vitro only in the large intestine and its content. This formation is probably of bacterial origin. Under a variety of experimental conditions we were unable to demonstrate any formation of piperidine in brain from cadaverine. Biosynthesis in vitro of [3H]-piperidine from D,L-[3H]-pipecolic acid was very low in brain and kidney. With the exception of brain and kidney, no other organs showed any formation of [3H]-piperidine. Neither MAO nor DAO inhibition influenced [3H]-piperidine formation in the large intestine with its content. Following 1 hr incubation at 37 degrees C under aerobic conditions, the levels of [14C]-pipecolic acid and [3H]-piperidine recovered from mouse brain homogenate did not indicate any significan...Continue Reading

References

Aug 1, 1977·Acta Physiologica Scandinavica·L Persson
Sep 1, 1979·Journal of Neurochemistry·Y NomuraE G Giacobini
Feb 1, 1978·Journal of Neurochemistry·Y E Chang
Mar 8, 1976·Biochemical and Biophysical Research Communications·Y F Chang
Oct 1, 1974·The Biochemical Journal·N Seiler, M J Al-Therib
Nov 8, 1974·Nature·M Stepita-Klauco, H Dolezalova
Dec 1, 1974·Biomedical Mass Spectrometry·N Seiler, H H Schneider
May 31, 1974·Brain Research·H DolezalovaR Fairweather
Jun 4, 1971·Brain Research·P D Gatfield, E Taller
Jan 1, 1983·Journal of Neuroscience Research·J G OrtizT Schmidt-Glenewinkel
Nov 1, 1980·Neurochemical Research·Y NomuraE Giacobini

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Citations

Feb 24, 2009·Critical Reviews in Food Science and Nutrition·Ismail Al BulushiGary A Dykes
May 31, 2012·Nutritional Neuroscience·Mao NagasawaMitsuhiro Furuse

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