Metabolism of circulating disaccharides in man and the rat

The Journal of Clinical Investigation
E Weser, M H Sleisenger

Abstract

The metabolism of circulating disaccharides was studied in adult humans and rats. After iv infusions of 10 g of either lactose, sucrose, or maltose in four adults, no rise in blood glucose was noted. A mean of 8.7+/-1.89 g of the lactose and 6.3+/-1.39 g of the sucrose was excreted in the 24-hour urine sample. Only 0.11+/-0.03 g of the infused maltose was recovered in the urine, suggesting that the maltose was metabolized.After injection of (14)C-labeled lactose and sucrose in rats, 6.2+/-2.7 and 7.6+/-2.4%, respectively, was oxidized to (14)CO(2) in 24 hours; 62.1+/-13.5 and 68.4+/-10.8% of the respective disaccharides was excreted into the urine. Conversely, after injection of (14)C-labeled maltose 54.6+/-7.0% was oxidized to (14)CO(2) and 4.8+/-3.9% excreted in the urine. The per cent of maltose oxidized to CO(2) was similar to that of glucose. In addition to small intestinal mucosa, homogenates of rat kidney, brain, and liver as well as serum were found to have measurable maltase activities. The role of these tissue maltases in the metabolism of circulating maltose and maltosyloligosaccharides is discussed.

References

Mar 28, 1966·Biochimica Et Biophysica Acta·O G GödekenJ M Olavarría
Nov 1, 1957·The American Journal of Digestive Diseases·R SANTINIC E BUTTERWORTH
Jun 1, 1958·Archives of Biochemistry and Biophysics·J A GOLDBARGA M SELIGMAN
Nov 1, 1961·The Journal of Pediatrics·H BICKEL
Jan 10, 1963·The New England Journal of Medicine·J D GRYBOSKIH M SPIRO
Aug 17, 1963·Lancet·S AURICCHIOA PRADER
Sep 1, 1963·Acta Physiologica Scandinavica·A DAHLQVIST, D L THOMSON
May 1, 1964·Acta Physiologica Scandinavica·A DAHLQVIST, D L THOMSON
Nov 12, 1964·The New England Journal of Medicine·G R PLOTKIN, K J ISSELBACHER
Mar 1, 1965·The Journal of Clinical Investigation·G M GRAY, F J INGELFINGER
May 1, 1955·The Journal of Clinical Investigation·N DEANE, H W SMITH
Jul 1, 1960·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A M RUTENBURGR T LANG

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Next ❯

Citations

Nov 1, 1975·European Journal of Intensive Care Medicine·H Förster, I Hoos
Oct 29, 1976·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·U SprandelR Scholz
May 15, 1976·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·K Yoshikawa, T Oda
Jul 1, 1968·The American Journal of Digestive Diseases·G C Cook, G R Howells
May 1, 1982·Canadian Anaesthetists' Society Journal·K AonoK Satoh
Feb 18, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M EnokiboriK Mori
Aug 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G C DaherK W Miller
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·M H GiroixW J Malaisse
Feb 15, 1975·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M FloresE A Young
Oct 1, 1976·Food and Cosmetics Toxicology·J C PhillipsA G Lloyd
Jun 1, 1971·The Journal of Pediatrics·T F RoeW G Ng
Jul 1, 1997·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P Baldrick, D G Bamford
Sep 17, 2002·Kidney International. Supplement·James B MoberlyMarsha Wolfson
Apr 19, 2008·Obstetrical & Gynecological Survey·Cynthia S GubbelsM Estela Rubio-Gozalbo
Oct 1, 1974·The Journal of Pharmacy and Pharmacology·B ClarkJ T Ritchie
May 1, 1986·Archives of Disease in Childhood·M BrivetJ L Dufier
May 1, 1971·The Journal of Clinical Investigation·J M Young, E Weser
Aug 1, 1997·Drug Metabolism Reviews·K D LawsonC D Hassall
Aug 31, 2010·Medical Hypotheses·Zhan-Jun ShuFu-you Liu
Aug 1, 1972·Metabolism: Clinical and Experimental·V VítekR A Cowley
Aug 1, 1989·The Journal of Pediatrics·M BrivetA Lemonnier
Mar 31, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R C Reynolds
Sep 1, 1981·JPEN. Journal of Parenteral and Enteral Nutrition·E A YoungE Weser
Sep 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·E A Young
Dec 5, 2017·The British Journal of Nutrition·Grégory PimentelGuy Vergères
Dec 4, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·J A Diaz-BuxoL Gotloib
Feb 12, 2020·Molecular Nutrition & Food Research·Xin Qi, Richard F Tester
Oct 19, 1977·Pflügers Archiv : European journal of physiology·S Silbernagl
Sep 1, 1976·Zeitschrift für Ernährungswissenschaft·G Berg, F Matzkies
Oct 26, 2018·PloS One·Nichole F Huntley, John F Patience
Sep 1, 1979·Zeitschrift für Ernährungswissenschaft·H H Schwartz, H Reinauer
Jun 1, 1976·Zeitschrift für Ernährungswissenschaft·C Finke, H Reinauer
Oct 1, 1977·Klinische Wochenschrift·F H SchmidtH F Kühnle
Sep 1, 1976·Zeitschrift für Ernährungswissenschaft·H FörsterS Boecker
Jun 1, 1976·Klinische Wochenschrift·M HaslbeckH Mehnert
Sep 1, 1976·Zeitschrift für Ernährungswissenschaft·H Förster, I Hoos
Aug 2, 2019·Scientific Reports·Puneet BaggaRavinder Reddy

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