Metabolism of classical cannabinoids and the synthetic cannabinoid JWH-018

Clinical Pharmacology and Therapeutics
M K SuR S Hoffman

Abstract

Although the putative pharmacological targets of synthetic cannabinoids (SCBs) abused in "K2" and "Spice" are similar to Δ(9) -tetrahydrocannabinol (Δ(9) -THC), it remains unclear why SCB toxicity is similar yet different from marijuana. There are obvious potency and efficacy differences, but also important metabolic differences that help explain the unique adverse reactions associated with SCBs. This brief review discusses the limited research on the metabolism of the SCB JWH-018 and contrasts that with the metabolism of Δ(9) -THC.

References

Jun 12, 2009·Drug Metabolism Reviews·Shu-Feng ZhouBalram Chowbay
Jul 13, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Krishna C ChimalakondaAnna Radominska-Pandya
May 9, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kathryn A SeelyLiana Fattore
Aug 21, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Krishna C ChimalakondaJeffery H Moran

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Citations

Mar 25, 2015·Clinical Pharmacology and Therapeutics·B Le Foll, R F Tyndale
Mar 14, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ju-Hyun KimHye Suk Lee
Apr 11, 2017·Journal of Science and Medicine in Sport·Michael C Kennedy
Apr 17, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tae Yeon KongHye Suk Lee
Oct 21, 2016·Nursing·Jeffrey PhillipsRichard Hsu
Feb 22, 2018·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Jonathan S ZipurskyMargaret Thompson
Apr 23, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Jan 12, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Katharina M Schenk-JaegerRudolph Pfab
Feb 25, 2017·Nursing Management·Jeffrey PhillipsRichard Hsu
May 16, 2018·The Western Journal of Emergency Medicine·Payal SudAdam Berman
Jul 25, 2018·Archives of Pharmacal Research·Tae Yeon KongHye Suk Lee
Oct 4, 2019·Cannabis and Cannabinoid Research·Marcel O Bonn-MillerDonald Abrams
Jun 6, 2016·The American Journal of Case Reports·Thiru ChinnaduraiRaji Ayinla
Dec 5, 2019·ACS Chemical Neuroscience·Adam Worob, Cody Wenthur

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