PMID: 8592869Nov 1, 1995Paper

Metabolism of Cyanox in the rat. I. Absorption, disposition, excretion and biotransformation

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Yoshitaka TomigaharaH Yamada

Abstract

1. To examine the metabolic fate of Cyanox [O-4-cyanophenyl O, O-dimethyl phosphorothioate, cyanophos, CYAP], rats of both sexes were administered [phenyl-4C]Cyanox as a single oral dose at levels of 0.5 mg/kg (low-dose group) or 25 mg/kg (high-dose group), or as multiple doses at 50 mg/kg/day once daily for 7 days (repeat-dose group). 2. The radiocarbon was almost completely eliminated from rats within 7 days after administration in both low- and high-dose groups. 14C-recoveries (expressed as % relative to the dosed 14C) in faeces and urine were 2-3 and 95-96% respectively for the low-dose and 13-14 and 86% respectively for the high-dose. 3. 14C-tissue residues on the seventh day after a single administration were generally low. Peak 14C-concentrations in blood and kidney occurred at 0.5 h (high-dose) and decreased rapidly thereafter. 4. Sex-related differences in the amounts of metabolites were observed in both groups. With the low-dose, the major metabolite was 4-cyanophenylsulphate in both sexes. However, in the high-dose, the major metabolites were 4-cyanophenyl sulphate and desmethylcyanoxon in males, but 4-cyanophenyl sulphate and desmethylcyanox in females. These findings indicate that the amounts or the types of enzyme...Continue Reading

References

Oct 21, 1991·Biochimica Et Biophysica Acta·S ImaokaY Funae
May 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K SaitoH Yamada
Jan 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H KanekoJ Miyamoto
Jan 1, 1980·Pharmacology & Therapeutics·A P Kulkarni, E Hodgson
Jan 1, 1982·Annual Review of Pharmacology and Toxicology·R A Neal, J Halpert
Dec 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Y TomigaharaH Yamada
Sep 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Y TomigaharaH Yamada

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