PMID: 9430609Jan 31, 1998Paper

Metabolism of cysteine is modified during the acute phase of sepsis in rats

The Journal of Nutrition
T MalmezatC Obled

Abstract

In vivo cysteine metabolism during the inflammatory state has been studied minimally. We investigated cysteine metabolism (i.e. taurine, sulfate and glutathione formation) using a single dose of [35S] cysteine in septic rats that had been injected with live Escherichia coli into the tail vein and in control, pair-fed rats. Cysteine metabolites were separated by ion exchange chromatography, and radioactivity was counted in the different fractions. Radioactivity incorporated in tissue proteins was also measured after protein precipitation. [35S]Sulfate production was significantly lower in septic rats than in pair-fed rats. [35S]Taurine contents were significantly lower only in kidneys, spleen and gastrointestinal tract of septic rats. The higher production of [35S] taurine in the livers (the major site of taurine production) of septic rats could have a protective effect against oxidation. Glutathione concentrations were also significantly greater in liver, spleen, kidneys and gastrocnemius muscle of septic rats, presumably in order to combat oxidative stress induced by sepsis. [35S]Cysteine incorporation in glutathione was significantly higher in spleen and kidneys but not in liver of septic rats compared to pair-fed rats. This ...Continue Reading

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Citations

May 10, 2000·The Journal of Nutrition·T MalmezatC Obled
Jan 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Yong-Ming YuVernon R Young
Jul 5, 2002·The Journal of Nutrition·Sabine MercierPhilippe Patureau Mirand
Jul 29, 2005·Current Microbiology·Joanna Saluk-JuszczakRafał Gowacki
Feb 14, 2006·The American Journal of Clinical Nutrition·Sabine MercierChristiane Obled
Aug 23, 2006·The Proceedings of the Nutrition Society·Simon Eaton
Nov 21, 2007·European Journal of Nutrition·Delphine GitenayEdmond Rock
Oct 11, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Alexander SemmlerMichael Linnebank
May 1, 2008·Animal : an International Journal of Animal Bioscience·I Savary-AuzelouxI Ortigues-Marty
Oct 19, 2013·European Journal of Nutrition·Karine VidalIsabelle Papet
Jul 27, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·V R Young, A M Ajami
Nov 30, 2000·American Journal of Physiology. Endocrinology and Metabolism·T MalmezatC Obled
May 21, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nancy M BenightDouglas G Burrin
Oct 7, 2011·Clinical Pharmacology and Therapeutics·G PickeringP Schoeffler
Jan 1, 2015·Healthcare·André F PiccolominiLarry C Lands
Jun 30, 2019·Journal of Animal Science·Anoosh RakhshandehAmanda R Rakhshandeh
Jan 8, 2020·Journal of Animal Science·Anoosh RakhshandehAmanda R Rakhshandeh
Mar 14, 2009·The Journal of Dairy Research·Federico Lara-VillosladaMónica Olivares
Jul 18, 2006·Cell Biology and Toxicology·J Saluk-JuszczakR Glowacki
Oct 29, 2015·European Journal of Human Genetics : EJHG·Christoph SponholzKlaus Huse
Oct 31, 2015·Aging Clinical and Experimental Research·Mélanie PougetIsabelle Papet
Jan 24, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Huili ZhangMadhav Bhatia
Jul 20, 2007·Journal of Dairy Science·F Lara-VillosladaJ Xaus
Aug 26, 2000·The Journal of Nutrition·C ChiarlaM Castagneto
Feb 15, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Christiane ObledDenis Breuillé
Jun 10, 2015·Journal of Zhejiang University. Science. B·Bin DaiJin-feng Miao
May 17, 2006·The Journal of Nutrition·Robert F Grimble
Jul 7, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·L GatéH Tapiero
Aug 21, 2007·The Journal of Nutritional Biochemistry·Sonia MétayerSophie Tesseraud

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