PMID: 1206747Nov 1, 1975Paper

Metabolism of dimethylnitrosamine to mutagenic intermediates by kidney microsomal enzymes and correlation with reported host susceptibility to kidney tumors

Journal of the National Cancer Institute
U Weekes

Abstract

Purified kidney microsomal enzymes from C3H/HeJ and Ha/1CR mice exhibited an unusually high capacity to generate mutagenic metabolites from dimethylnitrosamine (DMNA) when compared with similar enzyme preparations from BALB/cJ and RF/J mice. These results suggested that the DMNA-activating enzymes involved in mutagen formation were either present at higher levels or were more active in the kidneys of C3H/HeJ and Ha/ICR mice than in those of the other two strains. This strain difference correlated with the established susceptibility of these four strains to the neoplastic activity of DMNA.

Citations

Feb 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J R FryJ W Bridges
Oct 3, 2018·Toxicologic Pathology·Gordon C Hard
Aug 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·A H YangK B Cummings
Jan 1, 1976·Mutation Research·R Montesano, H Bartsch
Sep 1, 1987·Mutation Research·J B Guttenplan
Sep 1, 1977·Ecotoxicology and Environmental Safety·E J Olajos
Dec 1, 1978·Ecotoxicology and Environmental Safety·E J Olajos, F Coulston

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