PMID: 6163200Jan 1, 1980Paper

Metabolism of estrone sulphate by benign prostatic hyperplasia in vitro

Scandinavian Journal of Urology and Nephrology
K CarlströmO Tollbom


Homogenates of benign prostatic hyperplastic (BPH) tissue and abdominal muscle were incubated with [3H] estrone sulphate in the presence of NADH and NADPH. The metabolites were extracted with chloroform, isolated by thin layer chromatography (TLC) and identified by addition of 14C-labelled standards followed by sequential chromatography and acetylation. Both tissues transformed the substrate into [3H] estrone and [3H] estradiol-17 beta, but BPH tissue by far exceeded the abdominal muscle in this respect. Estriol and other polar metabolites could not be detected. The specific ability of BPH tissue to convert the major peripheral estrogen estrone sulphate into the terminal biologically active estrogen estradiol-17 beta further indicates an etiological role of estrogens in the development of human BPH.


Jun 1, 1976·Journal of Steroid Biochemistry·H SköldeforsM Furuhjelm
Jun 1, 1976·Biochemical Medicine·N BashirelahiJ D Young
Dec 1, 1977·Endocrinologia Japonica·T KodamaJ Shimazaki
Jan 1, 1978·Scandinavian Journal of Urology and Nephrology·H SköldeforsK Carlström
Feb 1, 1978·The Journal of Clinical Endocrinology and Metabolism·S M RifkaD L Loriaux
Aug 1, 1979·The Journal of Clinical Endocrinology and Metabolism·P EkmanJ A Gustafsson
Oct 15, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·R A HawkinsB Freedman
Mar 8, 1965·Biochimica Et Biophysica Acta·H F ACEVEDO, J W GOLDZIEHER

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Sep 29, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·P VadgamaM F Laker
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