Metabolism of Hydroxydibenzofurans, Methoxydibenzofurans, Acetoxydibenzofurans, and Nitrodibenzofurans by Sphingomonas sp. Strain HH69.

Applied and Environmental Microbiology
H HarmsP Fortnagel

Abstract

The metabolism of 11 substituted dibenzofurans by the dibenzofuran-degrading Sphingomonas sp. strain HH69 was investigated. Strain HH69 utilizes 2-, 3-, and 4-acetoxydibenzofuran as well as 2-, 3-, and 4-hydroxydibenzofuran as sole sources of carbon and energy. The degradation of acetoxydibenzofurans is initiated by hydrolysis of the ester bonds, yielding the corresponding hydroxydibenzofurans and acetate. Strain HH69 grew on 2-methoxydibenzofuran only after it was adapted to the utilization of 5-methoxysalicylic acid, whereas 3- and 4-methoxydibenzofuran as well as 2- and 3-nitrodibenzofuran were only cooxidized. During the breakdown of all eight hydroxy-, methoxy-, and nitrodibenzofurans studied here, the corresponding substituted salicylic acids accumulated in the culture broth. In the cases of 2- and 3-hydroxydibenzofuran as well as 2- and 3-nitrodibenzofuran, salicylic acid was also formed. Those four dibenzofurans which did not serve as carbon sources for strain HH69 were converted to a nonutilizable salicylic acid derivative. From turnover experiments with the mutant HH69/II, which is deficient in meta-cleavage, 2,2(prm1),3,4(prm1)-tetrahydroxybiphenyl, 2,2(prm1),3-trihydroxy-5(prm1)-methoxybiphenyl, 2,2(prm1),3-trihydro...Continue Reading

References

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Citations

Oct 20, 2000·Critical Reviews in Biotechnology·I GiavasisB McNeil
Dec 17, 2002·The Journal of General and Applied Microbiology·Hideaki NojiriToshio Omori
Nov 13, 2008·Applied Microbiology and Biotechnology·Andreas Stolz
Jul 25, 2007·Journal of Industrial Microbiology & Biotechnology·Sinéad M Ní ChadhainGerben J Zylstra
Aug 6, 2010·Journal of Industrial Microbiology & Biotechnology·Prashant Kumar JaiswalIndu Shekhar Thakur
Apr 9, 2013·Applied and Environmental Microbiology·Frank O AylwardMichael Poulsen
Jan 1, 1997·Biotechnology Advances·P V Bünz, S Schmidt
Feb 1, 1996·Applied and Environmental Microbiology·H WilkesW Francke

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