Abstract
Isothiocyanates (ITCs) derived from cruciferous vegetables have been shown to be promising agents against cancer in human cell culture, animal models, and in epidemiological studies. Several epidemiological studies have demonstrated an inverse relationship between intake of dietary isothiocyanates and the risk of cancers, particularly lung, colon, and breast. More importantly, the protective effects of dietary ITCs appear to be influenced by glutathione S-transferase (GST) genotype; specifically, individuals with glutathione S-transferase theta 1 (GSTT1) and glutathione S-transferase Mu 1 (GSTM1) null are better protected than those with GSTT1 and M1 positive. Although the majority of studies, especially those conducted in populations exposed to ITC rich diets, demonstrated such effects, there are a few studies that showed opposite or no association. While evidence for the interactions of dietary ITCs with GST genes is relatively strong, the reasons for the differential effects remain unclear. In this study, we examined one possible mechanism: whether subjects with null genotypes excrete ITCs at a slower rate than those with positive genotypes after drinking watercress juice, a rich source of ITCs. A total of 48 subjects, 28 GS...Continue Reading
References
Jan 15, 1977·The Biochemical Journal·G BrüsewitzW H Mennicke
Oct 15, 1995·The Biochemical Journal·R H KolmB Mannervik
Jan 17, 1995·Biochemical and Biophysical Research Communications·Y ZhangP Talalay
Sep 1, 1996·Chemical Research in Toxicology·D JiaoF L Chung
Jun 3, 2000·Carcinogenesis·J W LampeJ D Potter
Mar 10, 2001·Carcinogenesis·Y Zhang
Dec 26, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lingxiang YePaul Talalay
Jan 1, 2003·Carcinogenesis·Adeline SeowMimi C Yu
Nov 19, 2003·Analytical Biochemistry·Yan Ji, Marilyn E Morris
Oct 16, 2004·Pest Management Science·Dal-Soo KimGoon-Ho Joe
Apr 2, 2005·Cancer Causes & Control : CCC·Lisa I WangDavid C Christiani
Jul 16, 2005·Mutation Research·Adeline SeowMimi C Yu
Sep 17, 2005·Cancer Research·C Clifford ConawayFung-Lung Chung
Nov 1, 2005·Lancet·Paul BrennanFederico Canzian
Dec 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mariken J TijhuisEllen Kampman
Feb 28, 2006·Mutation Research·Gerlinde PappaClarissa Gerhäuser
Mar 4, 2008·Cancer Research·Rex MundayYuesheng Zhang
Jan 7, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Tram Kim LamAnthony J Alberg
Dec 22, 2009·The Journal of Biological Chemistry·Abeer Shokeer, Bengt Mannervik
Citations
Dec 5, 2015·SpringerPlus·Alam Zeb
Aug 8, 2014·Public Health Nutrition·Emily VogtmannXiao-Ou Shu
Aug 21, 2012·The Journal of Nutritional Biochemistry·Craig S CharronJanet A Novotny
Nov 28, 2015·Molecular Nutrition & Food Research·Stefanie PlatzSascha Rohn
Feb 12, 2015·Nutrition Research and Practice·Jeong-Hwa HanMyung-Hee Kang
Sep 23, 2016·Oncotarget·Jinyun LiuPeng Huang
May 12, 2011·Molecular and Cellular Biochemistry·Ana Cristina RamalhinhoLuiza Breitenfeld
Apr 19, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Ornanong TusskornVeerapol Kukongviriyapan
Apr 22, 2016·Cancer Prevention Research·Jian-Min YuanStephen S Hecht
Mar 10, 2016·Cancer Prevention Research·Stephen S HechtDorothy K Hatsukami