Metabolism of isothiocyanates in individuals with positive and null GSTT1 and M1 genotypes after drinking watercress juice.

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Marcin DybaFung-Lung Chung

Abstract

Isothiocyanates (ITCs) derived from cruciferous vegetables have been shown to be promising agents against cancer in human cell culture, animal models, and in epidemiological studies. Several epidemiological studies have demonstrated an inverse relationship between intake of dietary isothiocyanates and the risk of cancers, particularly lung, colon, and breast. More importantly, the protective effects of dietary ITCs appear to be influenced by glutathione S-transferase (GST) genotype; specifically, individuals with glutathione S-transferase theta 1 (GSTT1) and glutathione S-transferase Mu 1 (GSTM1) null are better protected than those with GSTT1 and M1 positive. Although the majority of studies, especially those conducted in populations exposed to ITC rich diets, demonstrated such effects, there are a few studies that showed opposite or no association. While evidence for the interactions of dietary ITCs with GST genes is relatively strong, the reasons for the differential effects remain unclear. In this study, we examined one possible mechanism: whether subjects with null genotypes excrete ITCs at a slower rate than those with positive genotypes after drinking watercress juice, a rich source of ITCs. A total of 48 subjects, 28 GS...Continue Reading

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Citations

Aug 21, 2012·The Journal of Nutritional Biochemistry·Craig S CharronJanet A Novotny
Nov 28, 2015·Molecular Nutrition & Food Research·Stefanie PlatzSascha Rohn
May 12, 2011·Molecular and Cellular Biochemistry·Ana Cristina RamalhinhoLuiza Breitenfeld
Apr 19, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Ornanong TusskornVeerapol Kukongviriyapan

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