Metabolism of mesocarb in the rat

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
M PolgárS Holly


1. Rats treated orally with [14C]mesocarb (I; 3-(1-methyl-2-phenyl[2-(14C]ethyl)-N-(phenylaminocarbonyl)sydnone imine) (50 mg/kg) excrete 35% of the radioactivity in 24 h urine and 51% in 48 h urine. 2. Only traces of unchanged drug were found in urine. Hydroxy-mesocarb (II), dihydroxy-mesocarb (III), amphetamine (VII) and the conjugates of II and III account for 86% of the urinary radioactivity. 3. Cannulated male rats excrete about 40% of the radioactivity in 30 h in bile, mainly as conjugates of II and III.


May 25, 2010·Analytical and Bioanalytical Chemistry·C GómezR Ventura
Dec 31, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Svetlana A AppolonovaVitaliy A Semenov
Jan 25, 2003·Journal of Biochemical and Biophysical Methods·Ju-Tsung Liu, Ray H Liu
Dec 6, 1996·Journal of Chromatography. B, Biomedical Applications·P Hemmersbach, R de la Torre
Apr 12, 2011·Analytical and Bioanalytical Chemistry·K DeventerP Van Eenoo
Jan 1, 1987·European Journal of Clinical Pharmacology·P MiskolcziC Göndöc
Apr 3, 2009·Archiv der Pharmazie·Mikko VahermoJari Yli-Kauhaluoma
May 25, 2002·Journal of Occupational and Environmental Medicine·John T Cody
Feb 9, 2011·The Journal of Pharmacology and Experimental Therapeutics·John A GrunerMaciej Gasior


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Metabolic Process, Cellular
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