Metabolism of mesocarb in the rat

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
M PolgárS Holly

Abstract

1. Rats treated orally with [14C]mesocarb (I; 3-(1-methyl-2-phenyl[2-(14C]ethyl)-N-(phenylaminocarbonyl)sydnone imine) (50 mg/kg) excrete 35% of the radioactivity in 24 h urine and 51% in 48 h urine. 2. Only traces of unchanged drug were found in urine. Hydroxy-mesocarb (II), dihydroxy-mesocarb (III), amphetamine (VII) and the conjugates of II and III account for 86% of the urinary radioactivity. 3. Cannulated male rats excrete about 40% of the radioactivity in 30 h in bile, mainly as conjugates of II and III.

References

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Citations

Related Concepts

Metabolic Process, Cellular
Urine
Amphetamine
Phenyl
Thyramine
Imines
Amphetamine Drug Class Measurement
Metabolic Pathway
Sydnones
Excretory Function

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