Metabolism of methapyrilene by rat-liver homogenate

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
R C Kammerer, D A Schmitz

Abstract

The metabolism of methapyrilene(I) in rat-liver 9000 g supernatant fraction produced four new metabolites positively identified by comparison of g.l.c. retention times and mass-spectral fragmentation patterns with those of authentic materials. These compounds are 2-thiophene-methanol(VI), 2-thiophenecarboxylic acid(VII), N-2-pyridyl-N'-dimethylethylenediamine(IX) and 2-aminopyridine(X). In addition, the previously known metabolite 2-[(2-thienylmethyl)amino]-pyridine(VIII) was also positively identified. Six other metabolites were tentatively identified by analysis of the mass-spectral fragmentation patterns of both the trimethylsilyl and the tertiary butyldimethylsilyl derivatives of each compound. These compounds are tentatively identified as: normethapyrilene(II), (hydroxypyridyl)-methapyrilene(XII), methapyrilenamide(XIV), (hydroxypyridyl)-normethapyrilene(XVI), (hydroxypyridyl)-desmethylmethapyrilenamide(XVII), and (hydroxypyridyl) methapyrilenamide(XVIII). Quantification of II, VI-X, XII and XIV account for approx. 65% of the metabolized methapyrilene.

References

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Citations

Sep 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R C KammererT Price
Sep 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R C Kammerer, D A Schmitz
Dec 11, 1992·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D W KellyW Slikker
Jul 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R C KammererK Kloc
Sep 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R C Kammerer, D A Schmitz
Dec 1, 1990·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M A Lampe, R C Kammerer
May 3, 2008·The Journal of Pharmacology and Experimental Therapeutics·Emma E GrahamB Kevin Park

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