Metabolism of nicotine by the isolated perfused dog lung.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
D M TurnerC T Dollery

Abstract

1. Metabolism of [14C]nicotine has been studied in the isolated perfused dog lung. [14C]Nicotine, 50 mug every 30 s for 10 min administered via the pulmonary artery, undergoes first pass metabolism to a small extent. [14C]Cotinine was detected in the venous blood. Of the injected activity, 6 percent was in the lung at the end of experiment; 60 percent being present as [14C]nicotine and 20 percent as [14C]nicotine-1'-oxide. 2. When [14C]nicotine was administered in cigarette smoke a greater degree of metabolism was observed at first pass. Pyrolysis products of [14C]nicotine also were present in the venous blood. Lungs after smoke exposure contained 30 percent of administered radioactivity, with a substantial proportion of [14C]nicotine-1'-oxide. 3. Administration of [14C]nicotine-labelled smoke to lung preparations, on closed circuit, gave significant amounts of [14C]cotinine and other metabolites over a 2 h period. Lung tissue contained approx. 40 percent of injected dose, of which 25 percent only was [14C]nicotine. Large proportions of [14C]cotinine and [14C]nicotine-1'-oxide were present but 45 percent of the activity was present as other unidentified pyrolysis products. [14C]Demethyl cotinine was detected.

References

Aug 8, 1972·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·T OkamotoB T So
Jan 1, 1974·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·A K ArmitageD A Wilson
Jan 1, 1974·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·A K ArmitageD M Turner
Jan 1, 1972·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·T Nakajima
Sep 1, 1973·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P JennerA H Beckett
Dec 1, 1969·The Biochemical Journal·D M Turner
Dec 1, 1969·European Journal of Pharmacology·P F Isaac, M J Rand
Jul 1, 1970·Journal of Applied Physiology·P M Rosenbloom, A D Bass
Nov 1, 1968·Archives of Environmental Health·T DalhamnR Rylander
Jul 1, 1964·Journal of Applied Physiology·J B WESTA NAIMARK

❮ Previous
Next ❯

Citations

Mar 26, 1998·European Journal of Drug Metabolism and Pharmacokinetics·G AislaitnerJ W Gorrod
Sep 1, 1977·Biochemical Pharmacology·J Leeds, D M Turner
Feb 1, 1980·Toxicology and Applied Pharmacology·G MitraJ J Ghosh
Dec 1, 1993·Pharmacology & Therapeutics·M J Seaton, E S Vesell
Jan 1, 1981·Toxicology·H M MehendaleY Ohmiya
Jun 1, 1987·Environmental Health Perspectives·S Kitamura
Feb 1, 1980·Journal of Pharmacological Methods·C M Macdonald, L E Boardman
Mar 23, 2007·European Journal of Pharmacology·Dariusz PogockiElzbieta Wałajtys-Rode
Aug 8, 1995·Biochemical Pharmacology·C E BerkmanJ R Cashman
May 1, 1988·Toxicology and Applied Pharmacology·A R DahlS J Whaley
Aug 1, 1977·Biochemical Pharmacology·R A Roth, C N Gillis
Dec 22, 1999·Preventive Medicine·E B DawsonW J McGanity
Jul 1, 1979·Acta Pharmacologica Et Toxicologica·K VähäkangasN T Kärki
Jun 11, 1998·Journal of Applied Physiology·A C Villablanca

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.