Metabolism of oestradiol by human mammary tumour 800 x g supernatants pretreated with dihydrolipoic acid

Cancer Letters
S G Richardson, E Killen

Abstract

Incubation of human mammary tumour 800 x g supernatants with [3H]oestradiol after preincubation for 10 min at 0 degrees C with 10 mM dihydrolipoic acid resulted in metabolism of oestradiol. This was noted in 12 malignant tumours, 8 of which contained measurable oestrogen receptor levels. In 2 benign tumours lacking measurable levels of receptor, dihydrolipoic acid pretreatment had no effect. This metabolism was further stimulated by pretreatment with NAD, NADP and the anti-oestrogen Tamoxifen (ICI 46,474). When incubations were carried out in an O2 atmosphere using oxygenated buffers, the effect was suppressed.

References

Oct 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N WilkingO Tollbom

Citations

Oct 1, 1968·The Journal of Clinical Endocrinology and Metabolism·T L Dao, P R Libby
Dec 1, 1973·The Journal of Clinical Endocrinology and Metabolism·W L McGuire, M DeLaGarza

Related Concepts

Metabolic Process, Cellular
Buffers
Tromlipon
Dihydrolipoic acid, sodium salt
Mammary Gland
Estradiol, (16 alpha,17 beta)-Isomer
Estradiol Measurement
Neoplasms
Tumor Lysis Syndrome
Tritium

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