Metabolism of oxidants by blood from different mouse strains

Biochemical Pharmacology
Daniela GiustariniRanieri Rossi

Abstract

Haemoglobins bearing reactive sulfhydryl groups have been shown to be able to interplay with glutathione in some detoxification processes. Blood from different mouse strains commonly used as experimental animal models, i.e., C57, DBA and ICR, was treated with oxidants with the aim of evaluating: (i) the involvement of protein SH groups in oxido-reductive reactions that are commonly carried out by glutathione and (ii) the impact of this phenomenon on blood-mediated metabolism of thiol reactants. All the main forms of glutathione (reduced, disulfide, and mixed disulfide with haemoglobin) were measured after oxidant treatment. Significant differences were found among the studied strains: DBA mice formed preferably mixed disulfides instead of glutathione disulfide, whereas the opposite behaviour was shown by C57 mice. Unexpectedly, the ICR strain resulted to be composed of three different subgroups (ICRa, ICRb, and ICRc), with the ICRa behaving similarly to the DBA strain, ICRc to the C57 strain, and ICRc showing an intermediate behaviour. These results are due to the different number of haemoglobin SH groups in the studied mouse strains. In particular, additional fast-reacting SH groups were found in haemoglobin from DBA, ICRa, an...Continue Reading

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Citations

Aug 15, 2013·Analytical and Bioanalytical Chemistry·Zoyne Pedrero ZayasDavid Amouroux
Nov 29, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Jay F StorzAngela Fago
Dec 8, 2009·Blood Cells, Molecules & Diseases·Graziano ColomboAldo Milzani
Apr 17, 2009·Free Radical Research·Ranieri RossiEleonora Cavarra
Dec 10, 2009·Medicine and Science in Sports and Exercise·Anastasios A TheodorouAthanasios Z Jamurtas
Jun 16, 2021·Amino Acids·Daniela GiustariniRanieri Rossi
Jun 27, 2012·Free Radical Biology & Medicine·Daniela GiustariniRanieri Rossi

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