PMID: 6413803Aug 1, 1983Paper

Metabolism of platelet-activating factor by blood platelets and plasma

Lipids
I AlamM J Silver

Abstract

High performance liquid chromatography in combination with a radioactivity detector was used to study the metabolism of platelet-activating factor (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by washed platelets, platelet-free plasma and platelet-rich plasma obtained from rabbits and humans. Degradation of platelet-activating factor to its 2-lyso derivative was observed in rabbit and human plasma. This degradation of platelet-activating factor in plasma was completely inhibited by diisopropylfluorophosphate and was partially inhibited by ethylenediamine tetraacetic acid. Washed platelets metabolized platelet-activating factor not only to the 2-lyso compound but also, by reacylation of this lyso intermediate, to an analogue of platelet-activating factor probably containing a long-chain acyl group at the sn-2 position. These transformations occurred, but to a lesser extent, in platelet-rich plasma.

References

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Citations

Jan 22, 1998·Medicinal Research Reviews·H Taguchi, W L Armarego
Jan 1, 1988·Veterinary Research Communications·J DawsonA D Sedgwick
Nov 1, 1987·Lipids·H K Mangold, N Weber
Jun 1, 1997·Archives of Pharmacal Research·S Y SonH W Chang
Jan 1, 1991·Molecular Aspects of Medicine·P A WardK J Johnson
Mar 1, 1988·Journal of Pharmacological Methods·A CalignanoP Persico
Oct 29, 1986·Biochimica Et Biophysica Acta·I Alam, M J Silver
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·D J LenihanT C Lee
Feb 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Marian NaniasHarold A Scheraga
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·M Liu, P V Subbaiah
May 1, 1989·The Journal of Clinical Investigation·F Lopez DiezM Sanchez Crespo
Oct 30, 1985·Biochemical and Biophysical Research Communications·H LachachiL Douste-Blazy
Oct 30, 1984·Biochemical and Biophysical Research Communications·M ChignardJ Benveniste
Nov 1, 1986·Thrombosis Research·G OstermannU Till
Apr 30, 1984·Biochemical and Biophysical Research Communications·G C White
Jun 1, 1987·Australian and New Zealand Journal of Medicine·W P SheridanG Morstyn
Jul 1, 1990·Acta Pathologica Japonica·S NakamuraT Watanabe

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