PMID: 6113827Mar 1, 1981Paper

Metabolism of poly (A)-containing mRNA in myocardium under normal physiological conditions and compensatory cardiac hyperfunction

Basic Research in Cardiology
F Z MEERSONO V Podobed

Abstract

Two fractions of mRNA poly A+ and poly A- mRNA have been found in rat heart muscle by the method of affinity chromatography. These fractions amount to 30 and 70% of the total RNA respectively. The relationship between poly A+ and poly A-mRNA in myocardium does not alter in heart hyperfunction and aging. The life-span of mRNA reduces to 2-3 hours in the beginning of the process of myocardium hyperfunction development; the lifespan of mRNA does not differ from the controls in prolonged heart hyperfunction (6 months). The rate of poly A+mRNA synthesis increases by 70% compared to controls in the early stage of heart hyperfunction; it falls below the control level in long-term hypertrophied myocardium. This decreases in the rate of mRNA transcription in compensatory heart hypertrophy can play an important role in wear of the organ and in premature development of aging changes in the heart.

References

Aug 1, 1978·Journal of Molecular and Cellular Cardiology·A F CutillettaR Zak
Oct 1, 1977·Nucleic Acids Research·T V Chernovskaya, M I Lerman
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A J OuelletteR A Malt
Dec 1, 1975·Molecular Biology Reports·E V LubimovaM I Lerman
Apr 2, 1976·Biochimica Et Biophysica Acta·A J OuelletteR A Malt
Feb 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·R SheldonJ Kates
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·A Przybyla, R C Strohman
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M E BuckinghamF Gros
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·B M PatersonD Yaffe
Feb 27, 1974·Biochemical and Biophysical Research Communications·H MondalS Sarkar
Jun 27, 1974·Biochimica Et Biophysica Acta·S J Kaufman, K W Gross

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Citations

Mar 1, 1983·Basic Research in Cardiology·J ZähringerN Pritzl

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