Metabolism of prostaglandins A1 and E1 in man

The Journal of Clinical Investigation
M GolubR Horton

Abstract

To investigate the in vivo whole blood metabolic clearance rates and sites of metabolism of prostaglandins A1 and E1 in man, constant infusions of the tritiated compounds were administered to normal subjects and to patients undergoing cardiac catheterization. The whole blood metabolic clearance rate of [3H]prostaglandin A1 in eight men was 5,003 +/- 864 liters/day (SD) or 2,546 +/- 513 liters/day per m2 (SD). Nonradioactive prostaglandin A1 was similarly infused in two subjects, and the metabolic clearance rates were determined, utilizing a specific radioimmunoassay. The clearance rates with this method correlated closely with those determined by the isotope infusions. Extraction studies of prostaglandin A1 showed that pulmonary, splanchnic, renal, and extremity perfusions resulted in 8.1 +/- 4.1, 56.1 +/- 10.1, 50.3 +/- 3.4, and 34.4 +/- 5.9% (SEM) removal, respectively. With [3H]=prostaglandin E1, the whole blood metabolic clearance rate was determined from the pulmonary artery concentration in three patients and averaged 4,832 +/- 1,518 liters/day (SD) or 2,686 +/- 654 liters/day per m2 (SD). Pulmonary extraction was 67.8 +/- 6.8% (SEM) and extremity removal averaged 6.6 +/- 4.9% (SEM). These results indicate that A prostagl...Continue Reading

References

Aug 1, 1975·The Journal of Clinical Endocrinology and Metabolism·P ZiaR Horton
Jan 1, 1967·The Journal of Clinical Endocrinology and Metabolism·R Horton, J F Tait
Oct 10, 1974·Prostaglandins·M S GolubR Horton
Dec 17, 1969·Biochimica Et Biophysica Acta·H VonkemanD A van Dorp
Aug 16, 1969·Nature·J C McGiffK K Ng
Nov 1, 1945·The Journal of Clinical Investigation·S E BradleyJ J Curry

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Citations

Jan 31, 1979·Pflügers Archiv : European journal of physiology·A Nizet
Jan 1, 1997·World Journal of Urology·M C TrussU Jonas
May 1, 1979·Intensive Care Medicine·J DussanF Lemaire
Jan 1, 1994·Surgery Today·E TotsukaM Konn
Jan 1, 1981·Lung·J A Pang, D M Geddes
Apr 1, 1997·European Journal of Drug Metabolism and Pharmacokinetics·M Foldvari, C J Oguejiofor
Feb 23, 2008·Pharmaceutical Research·Tsutomu IshiharaYutaka Mizushima
Jul 28, 2009·Pharmaceutical Research·Tsutomu IshiharaTohru Mizushima
Jan 1, 1981·Toxicology·H M MehendaleY Ohmiya
Sep 14, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yunhui ZhangJingkai Gu
Jan 1, 1993·Seminars in Roentgenology·G A Broderick, P Arger
Jan 1, 1978·Prostaglandins·E Granström
Jul 4, 2001·Journal of Clinical Anesthesia·T IijimaY Iwao
Apr 28, 2001·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·K KitanishiP Reinach
Jul 11, 1998·Critical Care Medicine·M KleenB Zwissler
Jan 1, 1990·British Journal of Urology·P SchramekP Porpaczy
Mar 21, 2006·Biochemistry. Biokhimii︠a︡·A I Hubich, M V Sholukh
Aug 1, 1981·Annals of the Rheumatic Diseases·M F MartinJ D Kirby
Nov 1, 1981·Postgraduate Medical Journal·S C Sharma
May 14, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Jiro EsakiRyuzo Sakata
Sep 1, 1976·Kidney International·R J AndersonR W Schrier
Sep 27, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Leila GobejishviliDaniell Hill
Jun 2, 2009·The Journal of Surgical Research·Akihito MutoToshiya Nishibe

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