Metabolism of prostaglandins within the pregnant uterus.

British Journal of Obstetrics and Gynaecology
M J Keirse, A C Turnbull

Abstract

The metabolism of E and F prostaglandins has been studied in both fetal and maternal tissues obtained from the pregnant human uterus. Both 15-hydroxyprostaglandin dehydrogenase and 13,14-prostaglandin reductase are shown to be widely distributed in these tissues. Comparison of the levels of enzyme activity in different tissues demonstrates that the greatest metabolism of prostaglandins takes place in the membranes and placenta and that there is much less in the myometrium and the decidua. The lowest enzyme activity was found in the umbilical cord, and no metabolism could be demonstrated in amniotic fluid or in umbilical venous blood. The significance of these findings is discussed.

References

Feb 1, 1976·British Journal of Obstetrics and Gynaecology·M J KeirseA C Turnbull
Feb 1, 1975·British Journal of Obstetrics and Gynaecology·M J KeirseA C Turnbull
Mar 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·W T PrinceH Rasmussen
Mar 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J Jarabak
Aug 1, 1973·Prostaglandins·M J Keirse, A C Turnbull
Nov 1, 1973·The Journal of Obstetrics and Gynaecology of the British Commonwealth·M J Keirse, A C Turnbull
Feb 1, 1974·The Journal of Obstetrics and Gynaecology of the British Commonwealth·M J KeirseA C Turnbull
Apr 1, 1974·The Journal of Obstetrics and Gynaecology of the British Commonwealth·K HillierM P Embrey
Aug 1, 1972·The Journal of Obstetrics and Gynaecology of the British Commonwealth·S M Karim, S D Sharma
Jul 1, 1971·Cardiovascular Research·S M KarimK Hillier
Aug 1, 1968·The Journal of Obstetrics and Gynaecology of the British Commonwealth·M P Embrey, D L Morrison
Feb 1, 1967·British Journal of Pharmacology and Chemotherapy·S M Karim

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Citations

Jan 1, 1977·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J LuengoJ Bennebroek Gravenhorst
Aug 1, 1978·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M J KeirseM D Mitchell
Aug 1, 1979·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M J KeirseJ Z Kendall
Nov 1, 1977·Prostaglandins·M D MitchellG D Thorburn
Feb 1, 1978·Prostaglandins·M D MitchellA C Turnbull
Apr 1, 1979·Prostaglandins·J G GerberA S Nies
Jan 1, 1989·Prostaglandins·R RomeroM D Mitchell
Oct 1, 1983·Prostaglandins, Leukotrienes, and Medicine·I MuchaS Bagdány
Feb 1, 1976·British Journal of Obstetrics and Gynaecology·M J Keirse, A C Turnbull
Feb 1, 1976·British Journal of Obstetrics and Gynaecology·M J KeirseA C Turnbull
Jan 1, 1977·British Journal of Obstetrics and Gynaecology·M D MitchellA C Turnbull
Feb 1, 1978·British Journal of Obstetrics and Gynaecology·M D MitchellA C Turnbull
Apr 1, 1979·British Journal of Obstetrics and Gynaecology·J G BibbyA C Turnbull
Mar 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Marianne ParentMichel A Fortier
Dec 1, 1988·American Journal of Obstetrics and Gynecology·A N HarrisM D Mitchell
May 1, 1988·Placenta·J J ErwichM J Keirse
May 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·W GuG D Thorburn
Oct 1, 1990·Early Human Development·A N Cakar
Mar 1, 1980·British Journal of Obstetrics and Gynaecology·H C WallenburgJ F Blacquière
Feb 15, 1982·American Journal of Obstetrics and Gynecology·J R OkitaJ M Johnston
Oct 1, 1983·Biochemical Medicine·N J Christensen, K Gréen
Jun 1, 1982·Biochemical Medicine·R K Kammula, R Artal
Dec 1, 1977·British Journal of Obstetrics and Gynaecology·M J KeirseA C Turnbull
May 1, 1980·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·R LackritzD Tulchinsky

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