PMID: 4005270Jun 14, 1985Paper

Metabolism of protein-free lipid emulsion models of chylomicrons in rats

Biochimica Et Biophysica Acta
T G Redgrave, R C Maranhão

Abstract

Emulsions were prepared by ultrasonication of mixtures of triolein, cholesteryl oleate, phosphatidylcholine and cholesterol in aqueous dispersions, then purified by ultracentrifugation. After injection into rats, the metabolism of the artificial, protein-free emulsions was comparable to the metabolism of chylomicrons collected from rat intestinal lymph during the absorption of fat. Like chylomicrons, the emulsion triacylglycerol was removed from the plasma more quickly than emulsion cholesteryl ester. Also like chylomicrons, much more emulsion cholesteryl ester than triacylglycerol appeared in the liver 10 min after injection, and only trace amounts appeared in the spleen. Because the artificial emulsions gained apolipoproteins when incubated with plasma, their metabolism was probably facilitated by the recipient rat plasma apolipoproteins and so, in rats made apolipoprotein-deficient by treatment with estrogen, the removal of emulsions from the plasma was slowed. Removal was also slowed in hyperlipidemic rats fed a high-fat, high-cholesterol diet to expand the plasma pools of the triacylglycerol-rich lipoproteins and remnants. The results indicate that the metabolism of lymph chylomicrons can be modeled by artificial, protein-...Continue Reading

References

May 12, 1975·Analytical Biochemistry·T G RedgraveC E West
Apr 11, 1969·Analytical Biochemistry·A Zlatkis, B Zak
May 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·L A Carlson, S Rössner
Jan 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·A ScanuK Kothary
Mar 1, 1970·The Journal of Clinical Investigation·T G Redgrave
Apr 4, 1966·Biochimica Et Biophysica Acta·S H Quarfordt, D S Goodman
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J P KaneH E Paulus
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·K V KrishnaiahG S Getz
May 1, 1982·The Journal of Clinical Investigation·S H QuarfordtB Schirmer
May 13, 1982·Biochimica Et Biophysica Acta·P W Connelly, A Kuksis
Nov 12, 1982·Biochimica Et Biophysica Acta·S GalP Hamosh
Aug 24, 1981·Biochimica Et Biophysica Acta·D W ErkelensJ A Glomset
Mar 1, 1980·The Journal of Clinical Investigation·F ShelburneS Quarfordt
Jan 1, 1980·Steroids·G Halperin, S Gatt
May 1, 1980·European Journal of Biochemistry·G Bengtsson, T Olivecrona

❮ Previous
Next ❯

Citations

Jan 1, 1993·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·A O DamiãoE C Quintão
Mar 17, 2004·The Journal of Nutritional Biochemistry·Ian J Martins, Trevor G Redgrave
Aug 21, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Katia A AlmeidaRaul C Maranhão
Dec 31, 2003·The Journal of Surgical Research·F Behzad KasraviHobart W Harris
Jan 16, 2003·Leukemia Research·Romélia P GonçalvesRaul C Maranhão
Feb 21, 2004·International Journal of Cardiology·Ana Paula M ChacraRaul C Maranhão
Apr 20, 2001·Advanced Drug Delivery Reviews·P C RensenT J van Berkel
Feb 5, 1999·Biochimica Et Biophysica Acta·R D HirataR C Maranhão
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·T HaraL Huang
May 7, 2009·The Journal of Biological Chemistry·Jelske N van der VeenFolkert Kuipers
Jan 24, 2006·Archives of Dermatological Research·Miguel Angelo De MarchiDorotéia R S Souza
Jan 28, 2004·Wiener klinische Wochenschrift·Wilfred Druml, Margot Fischer
Jan 29, 2016·Science Translational Medicine·Pirkka-Pekka LaurilaMatti Jauhiainen
Jul 13, 2002·Journal of Pharmaceutical Sciences·Mohannad ShawerD Robert Lu
Aug 31, 2000·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·L C SouzaA Campa
Apr 22, 2011·International Journal of Pharmaceutics·Yuta YoshizawaKazutaka Higaki
Apr 17, 1999·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·F KalfarentzosK Alexopoulos
Jul 1, 1991·Diabetes Research and Clinical Practice·T HiranoT Takahashi
May 10, 2000·The American Journal of Cardiology·R D SantosR C Maranhão
Apr 1, 1991·Journal of Microencapsulation·E S Vuaridel-Bonanomi, H G Weder
Jan 19, 2013·Journal of Liposome Research·Aranzazu Antelo, Javier S Perona
Oct 23, 2004·Drug Metabolism and Pharmacokinetics·Yasuyuki SuzukiMasahiro Hayashi
Jul 23, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Lulu XiaKemin Qi
Mar 1, 1995·Obesity Research·D H BessesenR H Eckel

❮ Previous
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