Metabolism of ribavirin in respiratory syncytial virus-infected and uninfected cells.

Antimicrobial Agents and Chemotherapy
D F Smee, T R Matthews

Abstract

The metabolism of ribavirin to its mono-, di-, and triphosphate derivatives was examined in uninfected and respiratory syncytial virus-infected cells. The degree of phosphorylation was dose dependent upon extracellular ribavirin concentration. The major species formed was the triphosphate, with mono- and diphosphates being approximately 12 and 4% of the triphosphate, respectively. Amounts of triphosphate formed in infected cells were up to 2.6-fold greater than those in uninfected cells. Upon drug removal, ribavirin triphosphate degradation was very rapid, with decay half-lives of 70 to 100 min. Actinomycin D inhibited triphosphate production and also neutralized the antiviral effect of ribavirin.

References

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R C WillisJ E Seegmiller
Aug 13, 1979·Biochemical and Biophysical Research Communications·B B GoswamiR A Smith
Mar 4, 1977·Annals of the New York Academy of Sciences·J P MillerJ Roboz
Jun 1, 1977·Antimicrobial Agents and Chemotherapy·B ErikssonB Oberg
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K K BironD J Nelson
Apr 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·D G StreeterL N Simon
Dec 4, 1980·Biochimica Et Biophysica Acta·Y YamadaN Ogasawara
Oct 1, 1981·Antimicrobial Agents and Chemotherapy·P A FurmanG B Elion
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A K FieldR L Tolman
May 1, 1983·Antimicrobial Agents and Chemotherapy·D F SmeeT R Matthews
Sep 1, 1983·Journal of Clinical Microbiology·C L Howell, M J Miller
Oct 1, 1983·Journal of Virological Methods·M W PonsO M Rochovansky
Jan 1, 1982·Antimicrobial Agents and Chemotherapy·J F HruskaR G Douglas
May 1, 1980·Antimicrobial Agents and Chemotherapy·J F HruskaC B Hall
Dec 1, 1980·Journal of Virology·D M LambertK Dorsch-Hasler

❮ Previous
Next ❯

Citations

Dec 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·V Knight, B Gilbert
Jan 1, 1990·The International Journal of Biochemistry·T Page, J D Connor
Aug 1, 2009·The Journal of Antimicrobial Chemotherapy·Donald F SmeeYousuke Furuta
Oct 1, 1987·Antimicrobial Agents and Chemotherapy·D F SmeeR A Smith
Apr 24, 2004·Antimicrobial Agents and Chemotherapy·Chin-Chung LinLi-Tain Yeh
Apr 12, 2014·Clinical Pharmacokinetics·Clara T M M de KanterDavid M Burger
Sep 4, 2010·Journal of Nucleic Acids·Motilal Maiti, Gopinatha Suresh Kumar
Jul 16, 2010·Leukemia & Lymphoma·Katherine L B Borden, Biljana Culjkovic-Kraljacic
Jan 26, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yin-Liang WuJian Zhao
Aug 19, 2008·Biochemical and Biophysical Research Communications·Keith TanKatherine L B Borden
Aug 27, 2014·Microbiology and Immunology·Sahoko KihiraHiroshi Komada
Jan 15, 2005·Virus Research·William B Parker
Oct 13, 2006·Journal of Pharmaceutical and Biomedical Analysis·Li-Tain YehChin-Chung Lin
Sep 12, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Wenkui LiFrancis L S Tse
Jan 5, 2002·Antiviral Chemistry & Chemotherapy·D F SmeeJ W Huggins
Apr 1, 1992·Clinical Microbiology Reviews·B Bean

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.