PMID: 9187378Apr 25, 1997Paper

Metabolism of selenite labelled with enriched stable isotope in the bloodstream

Journal of Chromatography. B, Biomedical Sciences and Applications
Kazuo T Suzuki, M Itoh

Abstract

The metabolism of selenium (Se) in the bloodstream of rats was studied using HPLC-ICP-MS with an enriched Se stable isotope, and the results were used as Se-specific indicators for Se nutritional status. Concentration of endogenous Se in plasma depended on dietary Se, while changes in concentrations and distributions of exogenous Se revealed its metabolic pathway. Namely, selenite was taken up by red blood cells and reduced to selenide, and then reappeared in plasma in a form bound selectively to albumin within 10 min, disappeared from plasma again within 30 min after injection. Then, the concentration of labelled Se started to increase slowly as selenoprotein P and extracellular glutathione peroxidase, and attained a maximum level at about 6 h after injection. The isotope ratio of endogenous to exogenous Se concentrations in plasma after 48 h post-injection was proposed to represent the Se-specific indicator in plasma reflecting the nutritional status of Se.

References

Oct 7, 1998·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·U TrafikowskaB A Zachara

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Citations

Oct 20, 2011·Analytical and Bioanalytical Chemistry·Sergio Cueto DíazJosé Ignacio García Alonso
Jan 27, 1999·Biochimica Et Biophysica Acta·K T SuzukiS Yoneda
Feb 27, 2003·Toxicology·Iván Csanaky, Zoltán Gregus
Nov 22, 2002·Food Additives and Contaminants·K T Suzuki, Y Ogra
May 23, 2006·BMC Infectious Diseases·Paul K DrainR Scott McClelland
Nov 24, 2007·Toxicology and Applied Pharmacology·Kazuo T SuzukiNoriyuki Suzuki
Aug 6, 2015·Chemical Research in Toxicology·Yasumi AnanYasumitsu Ogra
Dec 16, 1998·Toxicology and Applied Pharmacology·Y ShiobaraK T Suzuki
Jul 18, 2006·Toxicology and Applied Pharmacology·Kazuo T SuzukiNoriyuki Suzuki
Oct 27, 2004·Journal of Chromatography. a·Peter C UdenJulian F Tyson
Jun 20, 2008·Inorganic Chemistry·Mamoru HaratakeMorio Nakayama
May 8, 2014·Metallomics : Integrated Biometal Science·Claire M WeekleyHugh H Harris
Aug 1, 2018·Critical Care Medicine·Michael L MorrisonMark B Roth
Sep 11, 2008·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Kaori ShigetaNaoki Furuta
May 15, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Masafumi HongohMorio Nakayama
Apr 9, 2015·Critical Care Medicine·Akiko IwataMark B Roth
Dec 7, 2019·Metallomics : Integrated Biometal Science·Kazuaki Takahashi, Yasumitsu Ogra
Nov 12, 2010·Metallomics : Integrated Biometal Science·Yoshinari SuzukiNaoki Furuta
Nov 23, 2000·Chemical Research in Toxicology·J GailerH V Aposhian
Aug 1, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·Y Shiobara, K T Suzuki
Mar 23, 2006·Journal of Chromatography. a·C B'Hymer, J A Caruso

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