Metabolism of steroid hormones by Taenia solium and Taenia crassiceps cysticerci

The Journal of Steroid Biochemistry and Molecular Biology
P JiménezM C Romano

Abstract

Previous in vitro experiments showed that both, Taenia crassiceps and Taenia solium cysticerci have the ability to metabolize exogenous androstenedione to testosterone. Here we evaluate on the capacity of both cysticerci to synthesize several sex steroid hormones, using different hormonal precursors. Experiments using thin layer chromatography (TLC) showed that both cysticerci were able to produce (3)H-hydroxyprogesterone, (3)H-androstenedione and (3)H-testosterone when (3)H-progesterone was used as the precursor. They also synthesized (3)H-androstenediol and (3)H-testosterone when (3)H-dehydroepiandrosterone was the precursor. In addition, both cysticerci interconverted (3)H-estradiol and (3)H-estrone. These results, strongly suggest the presence and activity of the Delta4 and Delta5 steroid pathway enzymes, 3beta-hydroxysteroid dehydrogenase/Delta(5-4) isomerase-like enzyme (3beta-HSD), that converts androstenediol into testosterone; and the 17beta-hydroxysteroid dehydrogenase that interconverts estradiol and estrone, in both types of cysticerci.

References

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Citations

Jul 16, 2008·Parasitology Research·Ana María Fernández PresasMarta C Romano
Oct 20, 2009·Parasitology·Kaethe Willms, Rimma Zurabian
Apr 1, 2008·The Journal of Parasitology·Rimma ZurabianKaethe Willms
Feb 16, 2013·The Journal of Parasitology·Edda SciuttoCarlos Larralde
Feb 4, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Jianguo LiuDandan Yang
May 6, 2014·General and Comparative Endocrinology·R A ValdezM C Romano
Jun 19, 2012·BMJ Case Reports·Alan Scott SacerdoteOskar Salamon
Feb 11, 2012·General and Comparative Endocrinology·R A ValdezM C Romano
Jul 22, 2008·The Journal of Steroid Biochemistry and Molecular Biology·P VacchinaM C Romano
Apr 5, 2014·General and Comparative Endocrinology·A Aceves-RamosM C Romano
Feb 11, 2010·The Journal of Steroid Biochemistry and Molecular Biology·K M McNamaraD J Handelsman
Apr 24, 2013·General and Comparative Endocrinology·A Aceves-RamosM C Romano
Jan 12, 2012·International Journal for Parasitology·Graciela CárdenasAgnès Fleury
Apr 21, 2007·Endocrinology·Takanobu Mizuta, Kaoru Kubokawa

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