PMID: 3277209Jan 1, 1988Paper

Metabolism of steroid-modifying anticancer agents

Pharmacology & Therapeutics
S P Robinson, V C Jordan

Abstract

The application of steroid-modifying drugs as a strategy for the treatment of hormone-dependent cancers has gained increasing popularity during the past decade. However, it is important to point out and emphasize that very few of the agents were originally designed for their current application. Most were designed for other purposes, predominantly fertility control (e.g. LHRH agonists and the antiestrogens). Nevertheless, now it is possible to integrate their actions to design rational therapies. There are many reasons for the current interest in antisteroidal drugs. The initial euphoria over the potential ability of combination chemotherapy to cure breast and prostatic carcinoma has proved to be premature. Combination chemotherapy has many severe side-effects which limits patient acceptability, especially if the patient realizes that the likelihood of a cure is remote. In the main, antisteroidal therapies do not have many side-effects and those that do, e.g. aminoglutethimide, are the focus of increased efforts in drug design to produce increased drug specificity. Finally, there is a growing realization that hormone-dependent cancer control with a nontoxic, antisteroidal therapy may be the most acceptable approach currently av...Continue Reading

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Citations

Aug 28, 2002·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hiroyuki TakeiV Craig Jordan
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Aug 1, 1990·Breast Cancer Research and Treatment·S P RobinsonV C Jordan
Dec 1, 1988·European Journal of Cancer & Clinical Oncology·S P RobinsonV C Jordan
Jan 1, 1988·Critical Reviews in Clinical Laboratory Sciences·V C JordanW V Welshons
Jun 4, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·V Craig Jordan

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