PMID: 7012521Mar 1, 1981Paper

Metabolism of sterols by anaerobic Saccharomyces cerevisiae

Lipids
B C Sekula, W D Nes

Abstract

Anaerobically grown Saccharomyces cerevisiae retained the ability to transfer a C1-group to the C-24 position of a delta 24(25)-sterol and to reduce the delta 25(28)-bond of a 24-methylenesterol. Both desmosterol and 24-methylenecholesterol yielded 24 beta-methylcholesterol. However, when the substituent at C-24 was enlarged to a 24-ethylidene group (fucosterol), reduction of the delta 24(28)-bond did not occur. In no cases was a delta 7- or a delta 22-bond introduced. Because the delta 24(28)-bond was reduced in the absence of the delta 22-bond, the delta 22-bond is not an obligatory requirement for reduction.

References

Aug 23, 1976·Biochemical and Biophysical Research Communications·W R NesK Krevitz
Aug 7, 1972·Biochemical and Biophysical Research Communications·M FrybergA M Unrau
Aug 22, 1973·Journal of the American Chemical Society·M FrybergA M Unrau
Sep 1, 1972·Biochimica Et Biophysica Acta·R D Brandt, P Benveniste
Apr 5, 1965·Biochimica Et Biophysica Acta·J R TURNER, L W PARKS

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Citations

Sep 10, 2011·Chemical Reviews·W David Nes

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