Metabolism of tenoxicam in rats

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
S IchiharaR Joly


The structures of six metabolites of tenoxicam in rats (2 mg/kg, orally), elucidated by physicochemical analyses or the reverse-isotope dilution method, were 5'-hydroxytenoxicam (5% dose), 3-(methylsulphamoyl)-2-thiophenecarboxylic acid (9% dose), and the C-7 or C-8 O-glucuronide of tenoxicam (30% dose). The mechanism of formation of N-methylthiophenesulphimide, a possible precursor of 3-(methylsulphamoyl)-2-thiophenecarboxylic acid from tenoxicam, is discussed.


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Jan 1, 1992·European Journal of Clinical Pharmacology·M S al-GhamdiI S al-Saeed
Jan 1, 1992·European Journal of Drug Metabolism and Pharmacokinetics·T F WoolfT Chang
Feb 1, 1993·Photochemistry and Photobiology·A L NascimentoG Cilento
Jan 1, 1987·Drug Metabolism Reviews·M J LynchT J Newby
Jan 1, 1989·Drug Metabolism Reviews·T F Woolf, L L Radulovic
Sep 3, 2005·Biochemical and Biophysical Research Communications·Patrick M DansetteDaniel Mansuy
Nov 1, 1995·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J SchmidH Wachsmuth
Aug 1, 1992·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R J HickmanT J White
Apr 15, 1985·Biochemical Pharmacology·S IchiharaM Tateishi

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