PMID: 591837Dec 1, 1977

Metabolism of testosterone in the anterior pituitary gland and the central nervous system of the European starling (Sturnus vulgaris)

The Journal of Endocrinology
R MassaL Martini

Abstract

The metabolism of testosterone was studied in vitro in anterior pituitary, hypothalamic and hyperstriatal tissues taken from male European starlings in the autumn. In all the tissues studied, testosterone was converted into 5alpha-androstan-17beta-ol-3-one (5alpha-DHT), 5beta-androstan-17beta-ol-3-one (5beta-DHT), 5beta-androstane-3alpha,17beta-diol (5beta-THT), 5beta-androstane-3,-17-dione and androst-4-ene-3,17-dione. The 5alpha-DHT was produced in significantly greater amounts by the pituitary gland than by the hypothalamus and hyperstriatum. The amount of 5alpha-DHT produced, however, was very low in comparison with the amounts of 5beta-reduced metabolites. The amount of 5beta-reductase was also higher in the pituitary gland than in the two nervous tissues. The ratios between the production of 5beta-DHT, 5beta-THT and 5beta-androstane-3,17-dione were, however, different in the three tissues: 5beta-DHT was produced in the greatest quantities by the hyperstriatum, while the production of 5beta-THT, 5beta-androstane-3,17-dione and androst-4-ene-3,17-dione was greatest in pituitary tissue. The role of 5alpha- and 5beta-reduced metabolites in the pituitary gland and in the brain of birds is unknown, but some possibilities arisin...Continue Reading

Citations

Apr 24, 1995·Brain Research·K Tsutsui, T Yamazaki
Mar 1, 1983·Hormones and Behavior·C HardingM J Walters
May 1, 1978·Journal of Steroid Biochemistry·L MartiniM Motta
Nov 1, 1982·Journal of Steroid Biochemistry·C D Kochakian
Feb 1, 1990·Journal of Steroid Biochemistry·Y SugimotoB Tamaoki
Jan 1, 1990·Comparative Biochemistry and Physiology. A, Comparative Physiology·B A Schlinger, G V Callard
Dec 10, 1990·The Journal of Steroid Biochemistry and Molecular Biology·Y SugimotoB Tamaoki
Dec 3, 1999·The European Journal of Neuroscience·L A Bruins SlotF C Colpaert
Feb 20, 1989·Brain Research·E A Brenowitz, A P Arnold
Aug 1, 1983·General and Comparative Endocrinology·J BalthazartM A Ottinger
Dec 1, 1982·General and Comparative Endocrinology·P DevicheJ Balthazart
Nov 1, 1985·General and Comparative Endocrinology·M Pasmanik, G V Callard
Jun 1, 1979·Hormones and Behavior·J Balthazart, D Hirschberg
Mar 1, 1985·General and Comparative Endocrinology·L BottoniR Massa
Oct 1, 1984·General and Comparative Endocrinology·H KlandorfS Harvey
Dec 1, 1984·The Journal of Experimental Zoology·R Massa
Dec 1, 1984·The Journal of Experimental Zoology·M A OttingerH Opel

Related Concepts

Androstanes
Androstenedione
Aves
Lentiform Nucleus Structure
Organum Vasculosum Laminae Terminalis
Pituitary Gland, Anterior
Dihydroepitestosterone
Sterotate
5 beta-Androstane-3 alpha,17 beta-diol

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