Metabolism of topical retinaldehyde and retinol by mouse skin in vivo: predominant formation of retinyl esters and identification of 14-hydroxy-4, 14-retro-retinol

Experimental Dermatology
J O SassJ H Saurat

Abstract

We have previously shown that retinaldehyde (RAL), a natural metabolite of beta-carotene and retinol (ROL), can be used topically in human skin and exerts biological activity; it may be a convenient way to deliver multipotential vitamin A activity in epidermis. RAL can be converted enzymatically into 2 pathways: one leads to ROL (and then retinyl esters), the other to retinoic acid (RA). The aim of the present study was 2-fold: (i) to see if RAL is metabolised in vivo when topically applied on mouse skin, and (ii) if so, to analyse the occurrence and relative importance of the 2 metabolic pathways as compared to ROL. We studied by HPLC the metabolites detectable in mouse tail skin upon topical application of RAL and ROL. As compared to vehicle-treated controls, RAL-treated mouse skin contained low amounts of all-trans RA and 13-cis-RA, whereas ROL content increased 10-fold and retinyl esters 30-fold after RAL application. As compared to RAL, ROL-treated mouse skin showed no detectable RA, slightly less retinyl esters but a significant amount of 14-hydroxy-4, 14-retro-ROL (14-HRR), a metabolite not previously reported in the skin. 14-HRR was the predominant polar metabolite of ROL. These data indicate that keratinocytes metaboli...Continue Reading

References

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Citations

Jul 2, 1999·Experimental Dermatology·L DidierjeanJ H Saurat
Dec 1, 2007·Clinical Interventions in Aging·Siddharth MukherjeeGünther Weindl
Jan 15, 2010·Burns : Journal of the International Society for Burn Injuries·Matthias C AustPeter M Vogt
Oct 4, 2006·Dermatologic Therapy·Olivier SorgJean-Hilaire Saurat
Mar 20, 2008·Plastic and Reconstructive Surgery·Matthias C AustPeter M Vogt
Feb 26, 2020·Nanomaterials·Benchaphorn LimcharoenAlexa Patzelt
Nov 1, 1996·The Journal of Investigative Dermatology·L DidierjeanJ H Saurat
Oct 19, 2007·The Journal of Investigative Dermatology·Olivier SorgJean-Hilaire Saurat

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