PMID: 6528810Nov 1, 1984Paper

Metabolism of trimethoprim in neonatal and young pigs: comparative in vivo and in vitro studies

Acta Pharmacologica Et Toxicologica
N Gyrd-HansenF Rasmussen

Abstract

Metabolism of trimethoprim (TMP) was investigated in in vivo and in vitro experiments on 1 day (group A), 8 days (group B), and 60 days (group C) old piglets. In the in vivo studies piglets received an intravenous injection of 14C-trimethoprim. Urine was then collected for 3 hours after which the animals were killed. During the collection period 13, 24, and 40% of the dose was excreted in the urine in group A, B, and C, respectively. Trimethoprim and the following metabolites: Metabolite 1 and 4, minor metabolites, and conjugates were determined in plasma, liver, kidney, urine, and bile. The results show that newborn piglets have little capacity for oxidation of TMP while the ability to conjugate with glucuronic acid and sulfate seems somewhat higher. During the following 8 weeks a marked increase in the oxidative as well as conjugative potential took place. The microsomal fractions of liver and kidney were used for the in vitro metabolism studies of TMP. No metabolic activity could be demonstrated in the kidney preparations. Oxidative demethylation was just detectable in livers from the newborn piglets but increased considerably with age. Glucuronidation of metabolite 4 took place in the liver preparations from all three group...Continue Reading

References

Feb 1, 1975·Acta Pharmacologica Et Toxicologica·P Nielsen, F Rasmussen
Nov 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P Nielsen, L Dalgaard
Oct 1, 1975·Acta Pharmacologica Et Toxicologica·P Nielsen, F Rasmussen
Jun 1, 1973·Biochemical Pharmacology·C R Short, R D Stith
Sep 1, 1971·European Journal of Clinical Pharmacology·M EhrneboL O Boréus
May 1, 1984·Acta Pharmacologica Et Toxicologica·C FriisF Rasmussen
Jan 1, 1982·Pharmacology & Therapeutics·B M Assael

Citations

Oct 1, 1991·Pharmacology & Toxicology·P NielsenI Kraul
Nov 1, 1987·Pharmacology & Toxicology·P NielsenW J Xia
Aug 1, 1994·Journal of Veterinary Pharmacology and Therapeutics·L BrimerF Rasmussen
Nov 19, 2010·Journal of Veterinary Pharmacology and Therapeutics·S Modric, M Martinez
Sep 1, 1990·Pharmacology & Toxicology·R D MoshaP Nielsen
Dec 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·S GarwackiM Zaremba
Apr 16, 2015·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Keith K BurkhartDavid Jackson
Feb 4, 2016·Scientific Reports·Liye WangZonghui Yuan
Sep 1, 1990·Bulletin of Environmental Contamination and Toxicology·R D MoshaP Nielsen
Jan 1, 1988·The Veterinary Quarterly·G J de GraafT J Spierenburg
Jul 19, 2019·Frontiers in Pharmacology·Joske MillecamMathias Devreese
Jun 1, 1993·Journal of Veterinary Pharmacology and Therapeutics·S E EltomW S Schwark

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