PMID: 8952002Nov 14, 1996Paper

Metabolism of vasopressin, oxytocin and their analogues [Mpa1, D-Arg8]-vasopressin (dDAVP) and [Mpa1, D-Tyr(Et)2, Thr4, Orn8]-oxytocin (antocin) in human kidney and liver homogenates

Regulatory Peptides
A Fjellestad-Paulsen, S Lundin

Abstract

Information regarding the metabolic fate of the neurohypophyseal hormones arginine-vasopressin (AVP), oxytocin (OT) and their analogues in man is practically non-existent. The aim of the present study was to investigate the stability of oxytocin, vasopressin and their analogues dDAVP and [Mpa1-D-Tyr2(Et), Thr4, Orn8]-oxytocin (antocin) in human renal microvilli brush border membranes and in human liver membranes. After incubation the extent of degradation of the peptides was determined by reversed phase high-performance liquid chromatography (HPLC). The degradation of both AVP and OT was rapid in the presence of glutathione and human renal microvilli membranes. AVP, as well as dDAVP, was stable when incubated with microvilli membranes without glutathione, while OT was metabolized. The metabolization of the oxytocin analogue, antocin, also varied with the presence of glutathione. While in the absence of glutathione a more lipophilic peak eluted, a more hydrophilic peak was observed with glutathione on HPLC. The lipophilic peak was found to coelute with the truncated analogue [Mpa1, D-Tyr2 (Et), Thr4, desOrn8, Gly9]-oxytocin. No degradation occurred when the peptides were incubated with liver membranes. However, when using crude,...Continue Reading

References

Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J A Solis-HerruzoM T Muñoz-Yagüe
Apr 1, 1989·American Journal of Perinatology·L F AndersenP Melin
Jan 1, 1989·The Journal of Clinical Endocrinology and Metabolism·M C Postel-VinayR Rappaport
Nov 1, 1987·British Journal of Obstetrics and Gynaecology·M AkerlundP Melin
May 1, 1986·Acta Pharmacologica Et Toxicologica·H VilhardtJ Falch
May 1, 1973·The Biochemical Journal·S G George, J Kenny
Sep 1, 1974·The Biochemical Journal·A G Booth, A J Kenny
Mar 1, 1973·Acta paediatrica Scandinavica·A S AronsonJ L Mulder
Apr 1, 1984·Acta Endocrinologica·H Vilhardt, P Bie
Jun 1, 1982·The Journal of Endocrinology·T JanákyJ L Morgat
Feb 1, 1981·The Journal of Endocrinology·F A LászlóJ L Morgat
Mar 1, 1980·Endocrinology·R RabkinS A Unterhalter
Feb 1, 1994·American Journal of Obstetrics and Gynecology·T M GoodwinR Merriman

❮ Previous
Next ❯

Citations

Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·L GreiffC G Persson
Jan 7, 2014·The Journal of Endocrinology·Lucia GajdosechovaStefan Zorad
Sep 27, 2019·Frontiers in Behavioral Neuroscience·Raura Doreste-MendezAnnelyn Torres-Reveron
Jun 9, 2020·Paediatric Drugs·Elke GasthuysJohan Vande Walle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.