Metabolite profiling: from diagnostics to systems biology

Nature Reviews. Molecular Cell Biology
Alisdair R FernieLothar Willmitzer

Abstract

The concept of metabolite profiling has been around for several decades, but only recent technical innovations have allowed metabolite profiling to be carried out on a large scale - with respect to both the number of metabolites measured and the number of experiments carried out. As a result, the power of metabolite profiling as a technology platform for diagnostics, and the research areas of gene-function analysis and systems biology, is now beginning to be fully realized.

References

Feb 1, 1974·British Journal of Preventive & Social Medicine·P RogersJ Chamberlain
May 14, 1999·Current Opinion in Plant Biology·R N TretheweyL Willmitzer
Nov 4, 2000·Nature Biotechnology·O FiehnL Willmitzer
Jun 5, 2001·Nature Reviews. Genetics·J Quackenbush
Aug 4, 2001·Biochemical and Biophysical Research Communications·N AranìbarK H Ott
Aug 28, 2001·Proceedings. Biological Sciences·A Wagner, D A Fell
Nov 10, 2001·Annual Review of Genomics and Human Genetics·T IdekerL Hood
Feb 28, 2002·Journal of the American Chemical Society·Jens Meiler, Martin Will
Mar 2, 2002·Science·Eric H DavidsonHamid Bolouri
Jul 18, 2002·The Plant Cell·Robert HallRaoul Bino
Aug 23, 2002·Journal of Pharmaceutical and Biomedical Analysis·M WallesJ Pawliszyn
Oct 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Nitin S BaligaLeroy Hood
Nov 13, 2002·Omics : a Journal of Integrative Biology·Asaph AharoniDayan B Goodenowe
Mar 22, 2003·The Journal of Biological Chemistry·Marcus FehrWolf B Frommer
Aug 9, 2003·Nature Reviews. Drug Discovery·Jeremy K Nicholson, Ian D Wilson
Sep 16, 2003·EMBO Reports·Ewa Urbanczyk-WochniakAlisdair R Fernie
Sep 25, 2003·Annual Review of Plant Biology·Wolfram Weckwerth
Sep 27, 2003·Trends in Biotechnology·Esther J Kok, Harry A Kuiper
Oct 30, 2003·Journal of Proteome Research·Tomoyoshi SogaTakaaki Nishioka
Nov 25, 2003·Bioinformatics·Anthony L DuranLloyd W Sumner
Nov 25, 2003·The Plant Cell·Asaph AharoniHarro J Bouwmeester
Nov 26, 2003·Journal of Molecular Biology·Irene NobeliJanet M Thornton
Dec 24, 2003·Drug Discovery Today·John C Lindon
Jan 22, 2004·Nature Reviews. Genetics·Albert-László Barabási, Zoltán N Oltvai
Jun 16, 2004·Current Opinion in Microbiology·Douglas B Kell

❮ Previous
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Citations

Aug 14, 2012·Cellular and Molecular Life Sciences : CMLS·Toshihiro Obata, Alisdair R Fernie
Aug 4, 2010·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Amit GurDani Zamir
Sep 28, 2010·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Amit GurDani Zamir
Jun 16, 2012·Analytical and Bioanalytical Chemistry·Ntakadzeni E MadalaIan A Dubery
Jun 17, 2009·Applied Microbiology and Biotechnology·Guan-Nan LiuJian-Guo Jiang
Apr 26, 2011·Journal of Biomolecular NMR·Peter SanduskyDaniel Raftery
May 12, 2007·Journal of Fluorescence·Martin Bogner, Uwe Ludewig
Aug 18, 2006·Plant Molecular Biology·Eva M FarréLothar Willmitzer
Jan 11, 2007·Plant Molecular Biology·Nicolás FrankelFernando Carrari
May 7, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Eden P Go
Apr 16, 2005·Current Opinion in Biotechnology·Kirsi-Marja Oksman-Caldentey, Kazuki Saito
Sep 17, 2013·International Journal of Pharmaceutics·Rachid LadjAbdelhamid Elaissari
Jan 30, 2010·Parasitology·Richard A ScheltemaRainer Breitling
Mar 7, 2012·Analytical Chemistry·Florian RascheSebastian Böcker
May 2, 2013·Journal of Proteome Research·Neil J LoftusAlan J Barnes
Jul 4, 2013·Journal of Proteome Research·Miao JiangAiping Lu
Apr 10, 2007·Nature Methods·Erin E Carlson, Benjamin F Cravatt
Apr 5, 2007·Nature Protocols·Jan LisecAlisdair R Fernie
Feb 22, 2012·Nature Protocols·Gary J PattiGary Siuzdak
Feb 24, 2007·Nature Reviews. Drug Discovery·Hiroaki Kitano
Jul 17, 2008·Nature Reviews. Neuroscience·Florian Holsboer
Jun 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yoichi MinamiHiroki R Ueda
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sumit PaliwalSamir Mitragotri
Nov 1, 2011·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Kerstin ScheubertSebastian Böcker
Mar 21, 2013·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Imran RaufSebastian Böcker
Dec 23, 2004·Bioinformatics·Joachim KopkaDirk Steinhauser
May 10, 2011·Bioinformatics·Matti KankainenMatej Oresic
Jun 13, 2012·Bioinformatics·Franziska HufskySebastian Böcker
Mar 26, 2011·Journal of Experimental Botany·Andrej Kochevenko, Alisdair R Fernie
Feb 1, 2012·Journal of Experimental Botany·Dimas M RibeiroBernd Mueller-Roeber
Mar 9, 2010·Plant & Cell Physiology·Keiichi Mochida, Kazuo Shinozaki
Sep 26, 2006·Plant Physiology·Ute RoessnerAnthony Bacic

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