Metabolite Profiling in the Pursuit of Biomarkers for IVF Outcome: The Case for Metabolomics Studies

International Journal of Reproductive Medicine
C McRaeJ Fisher

Abstract

Background. This paper presents the literature on biomarkers of in vitro fertilisation (IVF) outcome, demonstrating the progression of these studies towards metabolite profiling, specifically metabolomics. The need for more, and improved, metabolomics studies in the field of assisted conception is discussed. Methods. Searches were performed on ISI Web of Knowledge SM for literature associated with biomarkers of oocyte and embryo quality, and biomarkers of IVF outcome in embryo culture medium, follicular fluid (FF), and blood plasma in female mammals. Results. Metabolomics in the field of female reproduction is still in its infancy. Metabolomics investigations of embryo culture medium for embryo selection have been the most common, but only within the last five years. Only in 2012 has the first metabolomics investigation of FF for biomarkers of oocyte quality been reported. The only metabolomics studies of human blood plasma in this context have been aimed at identifying women with polycystic ovary syndrome (PCOS). Conclusions. Metabolomics is becoming more established in the field of assisted conception, but the studies performed so far have been preliminary and not all potential applications have yet been explored. With furthe...Continue Reading

References

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Citations

May 24, 2017·The Cochrane Database of Systematic Reviews·Charalampos S SiristatidisDennis Vaidakis
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Fernanda Bertuccez CordeiroEdson Guimarães Lo Turco
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Maria Antonietta Castiglione MorelliAngela Ostuni
Mar 17, 2018·The Cochrane Database of Systematic Reviews·Charalampos S SiristatidisMarialena Trivella
Jul 15, 2020·International Journal of Molecular Sciences·Anna RajskaMichał Jan Markuszewski
Jun 10, 2016·Human Reproduction Update·Elisabetta Tosti, Yves Ménézo
Feb 7, 2020·Journal of Gynecology Obstetrics and Human Reproduction·Pierre-Emmanuel BouetPascale May-Panloup
Jun 12, 2021·Environment International·Audrey J GaskinsUNKNOWN EARTH Study Team
Aug 28, 2021·International Journal of Molecular Sciences·Giacomo LazzarinoPasquale Bilotta

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR
metabolomics
pregnancy test

Software Mentioned

ISI
Nanorespirometer

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